Department of Ophthalmology, Far Eastern Memorial Hospital, Ban-Chiao, New Taipei City, Taiwan, ROC.
Department of Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Sci Rep. 2020 Sep 8;10(1):14781. doi: 10.1038/s41598-020-71757-6.
Macular retinal layer thickness asymmetry indices, particularly for the ganglion cell layer, are promising early indicators of glaucomatous damage. We evaluated macular perfusion density asymmetry (MPDA) among normal, preperimetric glaucoma (PPG), and perimetric glaucoma (PG) eyes, and we tested the performance of MPDA in differentiating between control and glaucoma eyes with or without visual field (VF) defects. In this study, 116 eyes (39 normal, 27 PPG, and 50 PG eyes) with optical coherence tomography angiography images of the macula were analysed. No significant difference was found in outer and inner MPDA between the control and PPG groups. However, outer MPDA was significantly higher in the PG group than in the PPG group (p = 0.009). Asymmetry of perfusion density and structural parameters was compared; no significant difference was found between controls and glaucoma patients. Outer MPDA had significantly higher discrimination ability between PPG and PG than did macular ganglion cell layer-inner plexiform layer thickness asymmetry (p = 0.039). In conclusion, the discriminant capability of MPDA for discriminating between glaucoma patients with and without VF defects is significantly higher than that of structural asymmetry. MPDA may be helpful in monitoring glaucoma progression in clinical practice.
黄斑视网膜层厚度不对称指数，特别是神经节细胞层，是青光眼损伤的有前途的早期指标。我们评估了正常、青光眼前期（PPG）和青光眼（PG）眼中的黄斑灌注密度不对称（MPDA），并测试了 MPDA 在区分有或无视野（VF）缺损的正常和青光眼眼中的表现。在这项研究中，分析了 116 只眼（39 只正常眼、27 只 PPG 眼和 50 只 PG 眼）的黄斑光学相干断层扫描血管造影图像。在对照组和 PPG 组之间，外和内 MPDA 没有显著差异。然而，PG 组的外 MPDA 明显高于 PPG 组（p=0.009）。比较了灌注密度和结构参数的不对称性；对照组和青光眼患者之间没有显著差异。外 MPDA 在区分 PPG 和 PG 方面的辨别能力明显高于黄斑神经节细胞层-内丛状层厚度不对称（p=0.039）。总之，MPDA 区分有和无 VF 缺损的青光眼患者的判别能力明显高于结构不对称。MPDA 可能有助于在临床实践中监测青光眼的进展。
