Park Kee-Sup, Kim Jung-Tae, Lee Ka-Hyun, Lim Hyung-Bin, Lee Min-Woo
Department of Ophthalmology, Konyang University Hospital, Konyang University College of Medicine, #1643 Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea.
1.0 Eye Clinic, Daejeon, Republic of Korea.
Sci Rep. 2025 Jul 2;15(1):22928. doi: 10.1038/s41598-025-06774-4.
To evaluate the effectiveness of vertical asymmetry analysis of the macular microvasculature in high myopia patients with open-angle glaucoma (OAG). Participants were divided into two groups: those with high myopia (group 1) and those with both high myopia and OAG (group 2). Peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density (VD), and the absolute vertical difference of RNFL thickness (vdRNFL) and VD (vdVD) were compared. A logistic regression analysis determined the factors associated with OAG, and diagnostic accuracy was assessed using the area under the curve (AUC). Mean RNFL thickness was 91.2 ± 11.5 and 78.2 ± 13.0 μm (P < 0.001) and the VD of the full area was 17.5 ± 1.9 and 16.6 ± 2.4 mm (P = 0.040) in group 1 and group 2, respectively. The vdRNFL was not significantly different (P = 0.385), whereas the vdVD showed a significant difference (P < 0.001) between the groups. Multivariate analysis revealed that mean RNFL thickness (OR 0.88, P < 0.001) and vdVD (OR 3.07, P = 0.004) were significantly associated with OAG in high myopia patients. The AUC for vdVD was 0.82 (95% CI 0.73-0.90) and the combining mean RNFL thickness with vdVD yielded the highest AUC (0.91, 95% CI 0.85-0.96). For diagnosing OAG in high myopia patients, vertical asymmetry analysis of the macular microvasculature, combined with mean RNFL thickness, is advantageous.
评估黄斑部微血管垂直不对称分析在高度近视性开角型青光眼（OAG）患者中的有效性。参与者被分为两组：高度近视组（第1组）和高度近视合并OAG组（第2组）。比较了视乳头周围视网膜神经纤维层（RNFL）厚度、血管密度（VD）以及RNFL厚度（vdRNFL）和VD（vdVD）的绝对垂直差异。进行逻辑回归分析以确定与OAG相关的因素，并使用曲线下面积（AUC）评估诊断准确性。第1组和第2组的平均RNFL厚度分别为91.2±11.5和78.2±13.0μm（P<0.001），全区域的VD分别为17.5±1.9和16.6±2.4mm（P = 0.040）。两组之间vdRNFL无显著差异（P = 0.385），而vdVD有显著差异（P<0.001）。多变量分析显示，在高度近视患者中，平均RNFL厚度（OR 0.88，P<0.001）和vdVD（OR 3.07，P = 0.004）与OAG显著相关。vdVD的AUC为0.82（95%CI 0.73 - 0.90），将平均RNFL厚度与vdVD相结合产生了最高的AUC（0.91，95%CI 0.85 - 0.96）。对于诊断高度近视患者的OAG，黄斑部微血管垂直不对称分析与平均RNFL厚度相结合具有优势。
