Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA, Jengka, Pahang, Malaysia.
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Malaysia.
Nat Prod Res. 2021 Dec;35(24):6067-6072. doi: 10.1080/14786419.2020.1819273. Epub 2020 Sep 9.
Previous studies on species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, led to the isolation of eleven known xanthones, ananixanthone (), 9-hydroxycalabaxanthone (), dombakinaxanthone , thwaitesixanthone , caloxanthone B (), trapezifolixanthone (), β-mangostin , osajaxanthone ), caloxanthone A , calozeyloxanthone and rubraxanthone . The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cytotoxicity and nitric oxide production inhibitory activities of selected xanthones as well as the extracts were tested against HL-60 cells and RAW 264.7 murine macrophages, respectively. Among all tested compounds, β-mangostin exhibited appreciable cytotoxicity against HL-60 cells with the IC value of 7.16 ± 0.70 µg/mL and rubraxanthone exhibited significant nitric oxide inhibitory activity against LPS induced RAW 264.7 murine macrophages with the IC value of 6.45 ± 0.15 µg/mL.
先前对 种属的研究表明，存在着各种各样的生物活性黄烷酮和香豆素。对该植物进行的植物化学研究导致分离出 11 种已知的黄烷酮，分别为：ananixanthone ()、9-hydroxycalabaxanthone ()、dombakinaxanthone 、thwaitesixanthone 、caloxanthone B ()、trapezifolixanthone ()、β- 荜澄茄素、osajaxanthone 、caloxanthone A 、calozeyloxanthone 和 rubraxanthone 。这些化合物的结构通过 NMR 和 MS 等光谱技术进行了鉴定和阐明。对所选黄烷酮以及提取物的细胞毒性和一氧化氮产生抑制活性进行了测试，分别针对 HL-60 细胞和 RAW 264.7 鼠巨噬细胞。在所测试的所有化合物中，β- 荜澄茄素对 HL-60 细胞表现出相当的细胞毒性，IC 值为 7.16±0.70μg/mL，rubraxanthone 对 LPS 诱导的 RAW 264.7 鼠巨噬细胞表现出显著的一氧化氮抑制活性，IC 值为 6.45±0.15μg/mL。
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