Faculty of Applied Science Studies, Universiti Teknologi MARA, Kota Samarahan, Sarawak, Malaysia.
Department of Paraclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.
Nat Prod Res. 2023 Jun;37(12):2043-2048. doi: 10.1080/14786419.2022.2116021. Epub 2022 Aug 23.
Previous phytochemical investigations reported that have biosynthesized a wide range of bioactive phenolics such as xanthones and coumarins. The phytochemical study conducted on the stem bark of has led to the isolation of eight trioxygenated xanthones namely: 5-methoxytrapezifolixanthone , 5-methoxyananixanthone , caloxanthone C , 1,5-dihydroxy-3-methoxy-4-isoprenylxanthone , 6-deoxyisojacareubin , euxanthone , trapezifolixanthone , ananixanthone , together with three common triterpenoids, -sitosterol , friedelin , and stigmasterol . Furthermore, xanthones and were isolated for the first time as naturally occurring xanthones from the plant extract. The structures of these compounds were identified and elucidated using advanced spectroscopic techniques such as 1 D & 2 D NMR, MS, and FTIR. The neuroprotective property of selected compounds was tested through stroke model. Among all tested compounds, 1 µm of compounds , and showed significant neuroprotective activity via reduction of apoptosis by ∼ 50%.
先前的植物化学研究表明， 合成了广泛的生物活性酚类化合物，如黄烷酮和香豆素。对 的茎皮进行的植物化学研究导致分离出八种三氧化黄烷酮，分别为：5-甲氧基三匹枯灵酮、5-甲氧基南美花椒素、卡洛夫酮 C、1,5-二羟基-3-甲氧基-4-异戊烯基黄烷酮、6-去氧异嘉库瑞宾、艾乌萨酮、三匹枯灵酮、阿纳枯灵酮，以及三种常见的三萜类化合物，β-谷甾醇、friedelin 和豆甾醇。此外，黄烷酮 和 首次作为天然存在的黄烷酮从植物提取物中分离出来。这些化合物的结构通过 1D 和 2D NMR、MS 和 FTIR 等先进的光谱技术进行了鉴定和阐明。通过 中风模型测试了选定化合物的神经保护特性。在所有测试的化合物中，1μm 的化合物 、 和 表现出显著的神经保护活性，通过将凋亡减少约 50%。
