通过非接触式供氧设备提高模拟角膜表面的氧浓度。
Enrichment of Oxygen Concentration Over Simulated Corneal Surface Through Noncontact Oxygen Delivery Device.
出版信息
J Refract Surg. 2020 Sep 1;36(9):613-616. doi: 10.3928/1081597X-20200611-01.
PURPOSE
To demonstrate a noncontact device to enrich oxygen concentration during corneal cross-linking (CXL).
METHODS
An oxygen delivery device was tested in a laboratory mock-up. The device comprises a clear polycarbonate tube of 14 cm in length and 1.58 cm inner diameter. Compressed oxygen gas is delivered to the tube from a side opening. The oximeter was attached to a sampling tube 3 mm above the apex of a scleral lens that simulates the cornea. The lens was mounted on a mannequin face. During each experimental run, the oximeter reading was recorded manually every 30 seconds for 4.5 minutes after the flow regulator was opened to the preset flow rate. Three flow rates of 0.25, 0.50, and 1 L/min were tested with all three cornea-tube distances of 8, 10, and 14 mm.
RESULTS
The baseline oxygen concentration was 20.9%. The oxygen concentration reached plateau levels after 2 to 3.5 minutes. Oxygen measurements were averaged over the three time points in the plateau phase between 3.5 and 4.5 minutes. Atmospheric oxygen concentration above the simulated cornea was found to be strongly dependent on the oxygen flow rate up to 1 L/min. At the 1 L/min flow rate, 99% concentration was achieved at 8 to 10 mm of cornea-tube distances, and dropped to 90% at 14 mm.
CONCLUSIONS
Atmospheric oxygen concentration can be boosted to more than 90% using a noncontact device. This could potentially improve the effectiveness of accelerated CXL by boosting oxygen transport more than fourfold. [J Refract Surg. 2020;36(9):613-616.].
目的
展示一种非接触式设备，以提高角膜交联（CXL）过程中的氧浓度。
方法
在实验室模型中测试了一种氧气输送装置。该装置包括一个长 14 厘米、内径 1.58 厘米的透明聚碳酸酯管。压缩氧气从侧面开口输送到管中。血氧计连接到模拟角膜的巩膜透镜顶点上方 3 毫米的采样管上。透镜安装在人体模型的脸上。在每次实验运行中，打开流量调节器至预设流量后，手动记录血氧计读数，每 30 秒记录一次，共记录 4.5 分钟。测试了 0.25、0.50 和 1 L/min 三种流量，以及 8、10 和 14 毫米三种角膜-管距离。
结果
基线氧浓度为 20.9%。氧浓度在 2 至 3.5 分钟后达到稳定水平。在 3.5 至 4.5 分钟的稳定阶段，将三个时间点的氧测量值取平均值。模拟角膜上方的大气氧浓度强烈依赖于氧气流量，最高可达 1 L/min。在 1 L/min 的流量下，在 8 至 10 毫米的角膜-管距离下可达到 99%的浓度，而在 14 毫米时降至 90%。
结论
使用非接触式设备可将大气氧浓度提高到 90%以上。这可能通过将氧气输送量提高四倍以上来提高加速 CXL 的效果。[J Refract Surg. 2020;36(9):613-616.]。
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