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一项为期 12 周的运动方案可改善绝经后骨质疏松女性的功能状态:随机对照研究。

A 12-week exercise program improves functional status in postmenopausal osteoporotic women: randomized controlled study.

机构信息

Institute for Rehabilitation, School of Medicine, University of Belgrade, Belgrade, Serbia -

Institute for Rehabilitation, School of Medicine, University of Belgrade, Belgrade, Serbia.

出版信息

Eur J Phys Rehabil Med. 2021 Feb;57(1):120-130. doi: 10.23736/S1973-9087.20.06149-3. Epub 2020 Sep 9.

Abstract

BACKGROUND

Beside the importance of implementing physical activity in treatment of patients with osteoporosis, the multicomponent exercise program and assessment of its functional outcomes performed by five performance-based measures, have not been explored yet.

AIM

The present study evaluated the effect of the 12 weeks exercise program on functional outcomes of postmenopausal patients with densitometric diagnosed osteoporosis.

DESIGN

The study was designed as randomized control study.

SETTING

Female outpatients with diagnosed postmenopausal osteoporosis were included in the study.

POPULATION

The study included women from urban area.

METHODS

Patients were randomized in two groups: exercise group (EG) and control group (CG). Patients in the exercise group (N.=47) participated in a 12 weeks exercise program, which consisted of resistance training, balance exercise and aerobic exercise, while patients from control group (N.=49) had not participated in any exercise program during the intervention period. Functional outcomes determined by Time Up and Go Test (TUG), Sit To Stand test (STS) and One Leg Stance Test (OLST) were evaluated at baseline and 4 and 12 weeks after treatment, while Fall Efficacy Scale (FES-I) and Knowledge About Osteoporosis Questionnaire (OKAT-S) were assessed at baseline and after 12 weeks, respectively.

RESULTS

There were noticed statistically significant improvement in all observed measurements in EG after 4 and 12 weeks, respectively. Comparison between groups showed statistically significant difference in EG compared to CG in all functional outcomes in observed periods (P<0.001 for all). OLST significantly changed only in EG, not in CG, in both experimental periods. After 4 weeks, in CG there were no statistically significant changes in any of the monitored parameters, while after 12 weeks improvements were detected with TUG, STS, FES-I and OKAT-S.

CONCLUSIONS

Twelve weeks exercise program, as an effective, inexpensive and easily performed method, improved functional status in postmenopausal osteoporotic women.

CLINICAL REHABILITATION IMPACT

In the present study we found that supervised exercise program in postmenopausal osteoporotic female patients significantly improved their muscle strength and balance and decreased fear of falling. Thus, it is proposed to be a part of clinical protocol for osteoporosis treatment.

摘要

背景

除了在骨质疏松症患者的治疗中实施身体活动的重要性之外,多组分运动计划及其通过五项基于表现的措施评估其功能结果尚未得到探索。

目的

本研究评估了 12 周运动计划对经密度诊断患有骨质疏松症的绝经后患者功能结果的影响。

设计

本研究设计为随机对照研究。

设置

纳入经诊断患有绝经后骨质疏松症的女性门诊患者。

人群

本研究纳入了城市地区的女性。

方法

患者被随机分为两组:运动组(EG)和对照组(CG)。运动组(n=47)患者参加了为期 12 周的运动计划,该计划包括阻力训练、平衡运动和有氧运动,而对照组(n=49)患者在干预期间未参加任何运动计划。在治疗前、治疗后 4 周和 12 周时,通过“计时起立行走测试(TUG)”、“坐站测试(STS)”和“单腿站立测试(OLST)”评估功能结果,而在治疗前和治疗后 12 周时,通过“跌倒效能量表(FES-I)”和“骨质疏松症知识问卷(OKAT-S)”评估。

结果

EG 在治疗后 4 周和 12 周时,所有观察指标均有统计学意义的改善。组间比较显示,在所有观察期内,EG 与 CG 相比,在所有功能结果方面均有统计学差异(所有 P<0.001)。仅在 EG 中,OLST 在两个实验期均发生了统计学上的显著变化,而在 CG 中则没有。治疗后 4 周时,CG 中没有任何监测参数发生统计学上的显著变化,而治疗后 12 周时,TUG、STS、FES-I 和 OKAT-S 有所改善。

结论

12 周运动计划作为一种有效、廉价且易于实施的方法,改善了绝经后骨质疏松女性的功能状态。

临床康复影响

在本研究中,我们发现,监督下的运动计划可显著改善绝经后骨质疏松女性患者的肌肉力量和平衡能力,并降低跌倒恐惧。因此,建议将其纳入骨质疏松症治疗的临床方案中。

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