Ericsson C D, DuPont H L, Mathewson J J, Johnson P C, de la Cabada F J, Bitsura J A
Program in Infectious Diseases and Clinical Microbiology, University of Texas Medical School, Houston 77030.
J Clin Microbiol. 1988 May;26(5):1047-9. doi: 10.1128/jcm.26.5.1047-1049.1988.
Whether enteropathogens were eradicated or persisted in test-of-cure stool cultures from 251 patients with traveler's diarrhea, the durations of diarrhea were similar within the antimicrobial agent-treated (32 versus 33 h) and placebo-treated (82 versus 96 h) groups. Routine test-of-cure stool cultures can be useful for evaluating treatment failures and for assessing asymptomatic carriage of enteropathogens after treatment, but they are not mandated in the design of placebo-controlled antimicrobial treatment trials in traveler's diarrhea when the focus of the trial is clinical efficacy.
在251例旅行者腹泻患者的治愈后粪便培养中，无论肠道病原体是被根除还是持续存在，抗菌药物治疗组（32小时对33小时）和安慰剂治疗组（82小时对96小时）的腹泻持续时间相似。常规的治愈后粪便培养有助于评估治疗失败情况以及治疗后评估肠道病原体的无症状携带情况，但当试验重点是临床疗效时，在旅行者腹泻的安慰剂对照抗菌治疗试验设计中并不强制要求进行此类培养。
