阿米洛利可预防中性粒细胞减少患者中与两性霉素B相关的低钾血症。
Amiloride prevents amphotericin B related hypokalaemia in neutropenic patients.
作者信息
Smith S R, Galloway M J, Reilly J T, Davies J M
机构信息
University Department of Haematology, Royal Liverpool Hospital.
出版信息
J Clin Pathol. 1988 May;41(5):494-7. doi: 10.1136/jcp.41.5.494.
Abstract
Twenty neutropenic patients with various haematological disorders were randomised prospectively to receive either intravenous amphotericin B alone or amphotericin B and oral amiloride 5 mg twice a day for treatment of confirmed or suspected fungal infection. Patients receiving amiloride had a significantly higher plasma potassium (p less than 0.01), a significantly lower urinary potassium loss (p less than 0.01), and required significantly less potassium chloride supplementation to maintain their plasma potassium within the normal range (p less than 0.001). Amiloride was well tolerated, had no clinically important side effects, and provided effective control of plasma potassium in patients treated with amphotericin B.
摘要
20例患有各种血液系统疾病的中性粒细胞减少患者被前瞻性随机分组，分别接受单独静脉注射两性霉素B或两性霉素B加口服阿米洛利（每日2次，每次5毫克）治疗确诊或疑似真菌感染。接受阿米洛利治疗的患者血浆钾水平显著更高（p<0.01），尿钾丢失显著更低（p<0.01），并且维持血浆钾在正常范围内所需的氯化钾补充量显著更少（p<0.001）。阿米洛利耐受性良好，无临床重要副作用，并且能有效控制接受两性霉素B治疗患者的血浆钾水平。
相似文献
1
Amiloride prevents amphotericin B related hypokalaemia in neutropenic patients.阿米洛利可预防中性粒细胞减少患者中与两性霉素B相关的低钾血症。
J Clin Pathol. 1988 May;41(5):494-7. doi: 10.1136/jcp.41.5.494.
2
Spironolactone: is it a novel drug for the prevention of amphotericin B-related hypokalemia in cancer patients?
Eur J Clin Pharmacol. 2002 Jan;57(11):771-3. doi: 10.1007/s00228-001-0390-9.
3
Amiloride for the prevention of amphotericin B-induced hypokalemia and hypomagnesemia.氨氯吡咪预防两性霉素B引起的低钾血症和低镁血症。
Ann Pharmacother. 2000 Jan;34(1):94-7. doi: 10.1345/aph.19127.
4
The effect of amiloride on amphotericin B-induced hypokalaemia.
J Antimicrob Chemother. 2001 Jul;48(1):109-11. doi: 10.1093/jac/48.1.109.
5
Comment: spironolactone prevents amphotericin B-induced hypokalemia in neutropenic patients.评论：螺内酯可预防中性粒细胞减少患者中两性霉素B诱导的低钾血症。
Ann Pharmacother. 2000 Dec;34(12):1488. doi: 10.1345/aph.19375a.
6
Successful treatment of fungal infections in neutropenic patients with liposomal amphotericin (AmBisome)--a report on 40 cases from a single centre.脂质体两性霉素（安必素）成功治疗中性粒细胞减少患者的真菌感染——来自单一中心的40例报告
Leuk Lymphoma. 1992;7 Suppl:73-7. doi: 10.3109/10428199209061570.
7
Occurrence and improvement of renal dysfunction and serum potassium abnormality during administration of liposomal amphotericin B in patients with hematological disorders: A retrospective analysis.血液系统疾病患者使用两性霉素B脂质体期间肾功能不全及血清钾异常的发生与改善：一项回顾性分析
Diagn Microbiol Infect Dis. 2018 Feb;90(2):123-131. doi: 10.1016/j.diagmicrobio.2017.10.018. Epub 2017 Nov 7.
8
Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole.长期中性粒细胞减少患者真菌败血症的预防：一项关于静脉注射咪康唑的随机、双盲、安慰剂对照试验。
Am J Med. 1987 Dec;83(6):1103-10. doi: 10.1016/0002-9343(87)90949-1.
9
Itraconazole in neutropenic patients.中性粒细胞减少患者中的伊曲康唑
Chemotherapy. 1992;38 Suppl 1:23-6. doi: 10.1159/000239049.
10
Cost effectiveness of amphotericin B plus G-CSF compared with amphotericin B monotherapy. Treatment of presumed deep-seated fungal infection in neutropenic patients in the UK.两性霉素B联合粒细胞集落刺激因子（G-CSF）与两性霉素B单药治疗的成本效益。英国中性粒细胞减少患者疑似深部真菌感染的治疗
Pharmacoeconomics. 1999 Nov;16(5 Pt 2):543-50. doi: 10.2165/00019053-199916050-00010.
引用本文的文献
1
The Use of Amiloride and Sodium-Glucose Cotransporter 2 Inhibitors in Cisplatin-Induced Hypomagnesemia: A Case Report and Review of the Literature.氨氯吡咪和钠-葡萄糖协同转运蛋白2抑制剂在顺铂诱导的低镁血症中的应用：一例报告及文献综述
Cureus. 2024 Jun 17;16(6):e62546. doi: 10.7759/cureus.62546. eCollection 2024 Jun.
2
Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial.静脉注射碳酸氢钠与氯化钠联合用药与单纯静脉注射氯化钠水化治疗在降低两性霉素B肾毒性方面的比较：一项随机临床试验。
Res Pharm Sci. 2020 Nov 27;15(6):583-591. doi: 10.4103/1735-5362.301343. eCollection 2020 Dec.
3
N-acetyl cysteine in prevention of amphotericin- induced electrolytes imbalances: a randomized, double-blinded, placebo-controlled, clinical trial.N-乙酰半胱氨酸预防两性霉素 B 诱导的电解质失衡：一项随机、双盲、安慰剂对照的临床试验。
Eur J Clin Pharmacol. 2014 Apr;70(4):399-408. doi: 10.1007/s00228-014-1642-9. Epub 2014 Jan 21.
4
Role of diuretics and lipid formulations in the prevention of amphotericin B-induced nephrotoxicity.利尿剂和脂质制剂在预防两性霉素 B 诱导的肾毒性中的作用。
Eur J Clin Pharmacol. 2013 Jul;69(7):1351-68. doi: 10.1007/s00228-013-1472-1. Epub 2013 Jan 30.
5
Adverse drug reactions to systemic antifungals. Prevention and management.全身性抗真菌药物的药物不良反应。预防与管理。
Drug Saf. 1992 Sep-Oct;7(5):323-63. doi: 10.2165/00002018-199207050-00003.
本文引用的文献
1
Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia.针对长期发热且粒细胞减少的癌症患者的经验性抗生素和抗真菌治疗。
Am J Med. 1982 Jan;72(1):101-11. doi: 10.1016/0002-9343(82)90594-0.
2
Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats.在速尿诱导大鼠利尿期间，氨氯吡咪对肾脏镁清除率呈剂量依赖性降低。
Br J Pharmacol. 1983 Nov;80(3):421-8. doi: 10.1111/j.1476-5381.1983.tb10711.x.
3
Renal magnesium wasting associated with amphotericin B therapy.与两性霉素B治疗相关的肾性镁消耗
Am J Med. 1984 Sep;77(3):471-4. doi: 10.1016/0002-9343(84)90106-2.
4
Fungal infections in the immunocompromised host.免疫功能低下宿主的真菌感染
Clin Haematol. 1984 Oct;13(3):599-630.
5
Renal tubular acidosis due to amphotericin B.
N Engl J Med. 1968 Jan 18;278(3):124-30. doi: 10.1056/NEJM196801182780302.
6
Renal tubular acidosis due to amphotericin B nephrotoxicity.两性霉素B肾毒性所致的肾小管酸中毒。
Arch Intern Med. 1971 Feb;127(2):241-4.
7
Nephrotoxic effects of amphotericin B, including renal tubular acidosis.
Am J Med. 1969 Jan;46(1):154-62. doi: 10.1016/0002-9343(69)90067-9.
8
Amphotericin B, aminoglycosides, and hypomagnesaemic tetany.两性霉素B、氨基糖苷类药物与低镁血症性手足搐搦
Br Med J (Clin Res Ed). 1986 May 24;292(6532):1395-6. doi: 10.1136/bmj.292.6532.1395-b.
9
Ion transport in human colon in vitro.人结肠体外离子转运
Gastroenterology. 1987 Sep;93(3):441-8. doi: 10.1016/0016-5085(87)90904-8.
10
Renal physiology revisited: amiloride.重温肾脏生理学：氨氯地平。
Lancet. 1986 Aug 9;2(8502):326-8. doi: 10.1016/s0140-6736(86)90013-9.
Zotero 插件