Hynynen K, DeYoung D
Arizona Cancer Center, Tucson.
Int J Hyperthermia. 1988 May-Jun;4(3):267-79. doi: 10.3109/02656738809051103.
The effect of a muscle-bone interface on the temperature distribution during scanned, focused ultrasound hyperthermia was studied in vivo in dogs' thighs. The detailed temperature maps showed a sharp temperature maximum at the interface. The magnitude of the temperature elevation was between two and four times as large as obtained in resting muscle with similar intensities. The muscle tissue close to the bone could be heated to a therapeutic temperature level without overheating the bone when higher frequency or multiple-focused beams were used. The results showed that bone pain associated with ultrasound hyperthermia treatments is probably caused by extreme temperatures in bone, which can be avoided by sonicating the tumour in such a manner that the intensities at the bone surface are low enough so as not to cause large temperature elevations. Therefore, treatment planning which takes into account the location of bones is necessary for successful, clinical utilization of scanned, focused ultrasound hyperthermia.
在犬类大腿的活体研究中，探讨了肌肉 - 骨骼界面在扫描聚焦超声热疗过程中对温度分布的影响。详细的温度图显示在界面处有明显的温度峰值。与相似强度下静息肌肉相比，温度升高幅度为其两到四倍。当使用更高频率或多聚焦束时，靠近骨骼的肌肉组织可被加热到治疗温度水平而不会使骨骼过热。结果表明，与超声热疗相关的骨痛可能是由骨骼中的极端温度引起的，通过以骨表面强度足够低以至于不会引起大幅温度升高的方式对肿瘤进行超声处理，可以避免这种情况。因此，考虑骨骼位置的治疗规划对于扫描聚焦超声热疗在临床上的成功应用是必要的。
