Jimenez-Valdes Rocio J, Can Uryan I, Niemeyer Brian F, Benam Kambez H
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Department of Bioengineering, University of Colorado Denver, Aurora, CO, United States.
Front Bioeng Biotechnol. 2020 Aug 13;8:989. doi: 10.3389/fbioe.2020.00989. eCollection 2020.
Lung disorders such as chronic obstructive pulmonary disease (COPD) and lower respiratory tract infections (LRTIs) are leading causes of death in humans globally. Cigarette smoking is the principal risk factor for the development of COPD, and LRTIs are caused by inhaling respiratory pathogens. Thus, a thorough understanding of host-environment/pathogen interactions is crucial to developing effective preventive and therapeutic modalities against these disorders. While animal models of human pulmonary conditions have been widely utilized, they suffer major drawbacks due to inter-species differences, hindering clinical translation. Here we summarize recent advances in generating complex 3D culture systems that emulate the microarchitecture and pathophysiology of the human lung, and how these platforms have been implemented for studying exposure to environmental factors, airborne pathogens, and therapeutic agents.
诸如慢性阻塞性肺疾病（COPD）和下呼吸道感染（LRTIs）等肺部疾病是全球人类死亡的主要原因。吸烟是COPD发病的主要危险因素，而LRTIs是由吸入呼吸道病原体引起的。因此，全面了解宿主-环境/病原体相互作用对于开发针对这些疾病的有效预防和治疗方法至关重要。虽然人类肺部疾病的动物模型已被广泛应用，但由于种间差异，它们存在重大缺陷，阻碍了临床转化。在这里，我们总结了在生成模拟人类肺部微结构和病理生理学的复杂3D培养系统方面的最新进展，以及这些平台如何用于研究环境因素、空气传播病原体和治疗药物的暴露情况。
