Benam Kambez H
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Commun Eng. 2024 Sep 3;3(1):123. doi: 10.1038/s44172-024-00276-3.
Technology-based platforms offer crucial support for regulatory agencies in overseeing tobacco products to enhance public health protection. The use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes, has surged exponentially over the past decade. However, the understanding of the impact of ENDS on lung health remains incomplete due to scarcity of physiologically relevant technologies for evaluating their toxicity. This review examines the societal and public health impacts of ENDS, prevalent preclinical approaches in pulmonary space, and the application of emerging Organ-on-Chip technologies and bioinspired robotics for assessing ENDS respiratory toxicity. It highlights challenges in ENDS inhalation toxicology and the value of multidisciplinary bioengineering approaches for generating reliable, human-relevant regulatory data at an accelerated pace.
基于技术的平台为监管机构监督烟草产品以加强公共卫生保护提供了关键支持。在过去十年中，诸如电子烟等电子尼古丁传送系统（ENDS）的使用呈指数级激增。然而，由于缺乏用于评估其毒性的生理相关技术，对ENDS对肺部健康影响的了解仍不完整。本综述探讨了ENDS对社会和公共卫生的影响、肺部领域普遍的临床前研究方法，以及新兴的芯片器官技术和仿生机器人技术在评估ENDS呼吸道毒性方面的应用。它强调了ENDS吸入毒理学中的挑战，以及多学科生物工程方法对于加速生成可靠的、与人类相关的监管数据的价值。
