Jirtle R L
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
Int J Hyperthermia. 1988 Jul-Aug;4(4):355-71. doi: 10.3109/02656738809016490.
The preferential modification of tumour blood flow with chemical agents has been extensively investigated for the purpose of improving the treatment of tumours with ionizing radiation, chemicals and hyperthermia. In this paper I have utilized representative vasoactive drugs to demonstrate the various mechanisms via which tumour haemodynamics can be modified selectively. Chemicals which alter tumour blood flow by changing blood viscosity are also discussed. Of particular interest are the calcium entry blockers, flunarizine and verapamil, which have been shown to increase tumour blood flow, tumour oxygenation, tumour radiation sensitivity and the cytotoxicity of chemotherapeutic agents. These encouraging research results provide compelling evidence that these two drugs may prove to be useful adjuvants for radiation therapy.
为了改善肿瘤的电离辐射、化学药物及热疗效果，人们对利用化学药剂优先改变肿瘤血流进行了广泛研究。在本文中，我使用了具有代表性的血管活性药物来证明可选择性改变肿瘤血流动力学的各种机制。文中还讨论了通过改变血液粘度来改变肿瘤血流的化学物质。特别值得关注的是钙通道阻滞剂氟桂利嗪和维拉帕米，它们已被证明可增加肿瘤血流、肿瘤氧合、肿瘤放射敏感性以及化疗药物的细胞毒性。这些令人鼓舞的研究结果提供了有力证据，表明这两种药物可能被证明是放射治疗的有用辅助药物。
