Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Front Immunol. 2024 Oct 3;15:1472772. doi: 10.3389/fimmu.2024.1472772. eCollection 2024.
The tumor microenvironment (TME) provides essential conditions for the occurrence, invasion, and spread of cancer cells. Initial research has uncovered immunosuppressive properties of the TME, which include low oxygen levels (hypoxia), acidic conditions (low pH), increased interstitial pressure, heightened permeability of tumor vasculature, and an inflammatory microenvironment. The presence of various immunosuppressive components leads to immune evasion and affects immunotherapy efficacy. This indicates the potential value of targeting the TME in cancer immunotherapy. Therefore, TME remodeling has become an effective method for enhancing host immune responses against tumors. In this study, we elaborate on the characteristics and composition of the TME and how it weakens immune surveillance and summarize targeted therapeutic strategies for regulating the TME.
肿瘤微环境（TME）为癌细胞的发生、侵袭和扩散提供了必要的条件。最初的研究揭示了 TME 的免疫抑制特性，包括低氧水平（缺氧）、酸性条件（低 pH 值）、间质压力升高、肿瘤血管通透性增加和炎症微环境。各种免疫抑制成分的存在导致免疫逃逸，并影响免疫治疗的疗效。这表明靶向 TME 在癌症免疫治疗中的潜在价值。因此，TME 重塑已成为增强宿主对肿瘤免疫反应的有效方法。在本研究中，我们详细阐述了 TME 的特征和组成，以及它如何削弱免疫监视，并总结了调节 TME 的靶向治疗策略。
