Shang Tongxuan, Jia Ziqi, Li Jiayi, Cao Heng, Xu Hengyi, Cong Lin, Ma Dongxu, Wang Xiang, Liu Jiaqi
Department of Breast Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
School of Clinical Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
J Hematol Oncol. 2025 Mar 18;18(1):32. doi: 10.1186/s13045-025-01684-4.
In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature of solid tumors and is strongly associated with poor prognosis in cancer patients. Another significant portion of the development of acquired drug resistance is attributed to tumor stemness. Cancer stem cells (CSCs), a small tumor cell subset with self-renewal and proliferative abilities, are crucial for tumor initiation, metastasis, and intra-tumoral heterogeneity. Studies have shown a significant association between hypoxia and CSCs in the context of tumor resistance. Recent studies reveal a strong link between hypoxia and tumor stemness, which together promote tumor survival and progression during treatment. This review elucidates the interplay between hypoxia and CSCs, as well as their correlation with resistance to therapeutic drugs. Targeting pivotal genes associated with hypoxia and stemness holds promise for the development of novel therapeutics to combat tumor resistance.
在解决癌症耐药性的领域中，诸如疗效有限和治疗耐药等挑战仍然存在。缺氧是实体瘤的一个关键特征，并且与癌症患者的不良预后密切相关。获得性耐药发展的另一个重要部分归因于肿瘤干性。癌症干细胞（CSCs）是一小部分具有自我更新和增殖能力的肿瘤细胞，对于肿瘤的起始、转移和肿瘤内异质性至关重要。研究表明，在肿瘤耐药的背景下，缺氧与癌症干细胞之间存在显著关联。最近的研究揭示了缺氧与肿瘤干性之间的紧密联系，它们共同促进了治疗期间肿瘤的存活和进展。本综述阐明了缺氧与癌症干细胞之间的相互作用，以及它们与治疗药物耐药性的相关性。靶向与缺氧和干性相关的关键基因有望开发出对抗肿瘤耐药性的新型疗法。
