Zuo Zhenying, Jing Kaipeng, Wu Hongluan, Wang Shujun, Ye Lin, Li Zhihang, Yang Chen, Pan Qingjun, Liu Wei Jing, Liu Hua-Feng
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Front Physiol. 2020 Aug 7;11:935. doi: 10.3389/fphys.2020.00935. eCollection 2020.
Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).
线粒体自噬是一种进化上保守的过程，通过自噬机制选择性地清除受损或多余的线粒体。在本综述中，我们重点关注线粒体自噬分子机制的最新进展，以及线粒体自噬在生理和病理情况下如何促进细胞内稳态。我们还简要回顾并讨论了线粒体自噬与肾脏疾病之间的相互作用，强调其调节作为治疗急性肾损伤（AKI）、糖尿病肾病（DKD）和狼疮性肾炎（LN）等肾脏疾病的潜在有效治疗策略。
