基于iTRAQ的蛋白质组学揭示了产超广谱β-内酰胺酶细菌的潜在抗毒力靶点
iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-Producing .
作者信息
Wang Yan, Cong Shan, Zhang Qinghua, Li Ranwei, Wang Ke
机构信息
Department of Respiratory and Critical Care Medicine., The Second Hospital of Jilin University, Changchun, People's Republic of China.
Department of Urology, The Second Hospital of Jilin University, Changchun, People's Republic of China.
出版信息
Infect Drug Resist. 2020 Aug 19;13:2891-2899. doi: 10.2147/IDR.S259894. eCollection 2020.
PURPOSE
Treatment of infections with strains producing extended-spectrum beta-lactamases (ESBLs) is challenging due to the coexistence of multiple resistance mechanisms and the hypervirulent variant. Therefore, new targets or more effective treatment options aimed at ESBL-producing are urgently needed.
MATERIALS AND METHODS
Here, we collected ESBL-producing and non-ESBL isolates and studied their differences from a proteomic point of view.
RESULTS
We revealed treA, wza, gnd, rmlA, rmlC, rmlD, galE, aceE, and sucD as important virulence-related proteins in ESBL-producing , distinct from those in non-ESBL strains.
CONCLUSION
Our findings provide plausible anti-virulence targets and suggest new therapeutic avenues against ESBL-producing .
目的
由于多种耐药机制与高毒力变体共存，治疗产超广谱β-内酰胺酶（ESBLs）菌株引起的感染具有挑战性。因此，迫切需要针对产ESBLs菌株的新靶点或更有效的治疗方案。
材料与方法
在此，我们收集了产ESBLs菌株和非产ESBLs菌株的分离株，并从蛋白质组学角度研究它们的差异。
结果
我们发现treA、wza、gnd、rmlA、rmlC、rmlD、galE、aceE和sucD是产ESBLs菌株中与毒力相关的重要蛋白质，与非产ESBLs菌株中的不同。
结论
我们的研究结果提供了合理的抗毒力靶点，并提示了针对产ESBLs菌株的新治疗途径。
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