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Atypical Presentation of Erythroid/Megakaryocytic Leukemic Transformation of a Myeloproliferative Neoplasm Associated with Mutation and Loss of TP53.

作者信息

Chernak Brian J, Sen Filiz, Farnoud Noushin, Ayache Jad Bou, Zhang Yanming, DeWolf Susan, Rampal Raajit K

机构信息

Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Deparment of Medicine, NewYork-Presbyterian Weill Cornell Medical Center, New York, New York, United States.

出版信息

Hemasphere. 2020 Jul 15;4(4):e411. doi: 10.1097/HS9.0000000000000411. eCollection 2020 Aug.

DOI:10.1097/HS9.0000000000000411
PMID:32903909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7448368/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c0/7448368/c5b8a88cd53a/hs9-4-e411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c0/7448368/c5b8a88cd53a/hs9-4-e411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c0/7448368/c5b8a88cd53a/hs9-4-e411-g001.jpg

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2
Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53.高级形式的 MPNs 伴随着染色体异常，导致 TP53 失调。
Blood Adv. 2018 Dec 26;2(24):3581-3589. doi: 10.1182/bloodadvances.2018024018.
3
JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation.
伴有巨核细胞和红系分化的急性白血病中的JAK/丝裂原活化蛋白激酶途径激活及TP53突变
Leukemia. 2018 Aug;32(8):1842-1845. doi: 10.1038/s41375-018-0145-6. Epub 2018 Apr 24.
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MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis.MIPSS70：原发性骨髓纤维化移植年龄患者的突变增强国际预后评分系统。
J Clin Oncol. 2018 Feb 1;36(4):310-318. doi: 10.1200/JCO.2017.76.4886. Epub 2017 Dec 9.
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Extensive Bone Marrow Necrosis and Osteolytic Lesions in a Case of Acute Myeloid Leukemia Transformed from Polycythemia Vera.真性红细胞增多症转化为急性髓系白血病病例中的广泛骨髓坏死和溶骨性病变
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