Twist1：肾脏疾病中的一把双刃剑。
Twist1: A Double-Edged Sword in Kidney Diseases.
作者信息
Ren Jiafa, Crowley Steven D
机构信息
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA.
出版信息
Kidney Dis (Basel). 2020 Jul;6(4):247-257. doi: 10.1159/000505188. Epub 2020 Jan 17.
BACKGROUND
Twist1 is a basic helix-loop-helix domain containing transcription factor that regulates cell differentiation, migration, proliferation, survival, and inflammatory responses by transcriptionally regulating a wide range of downstream target genes. Its homologous protein, Twist2, shares many structural and functional similarities with Twist1.
SUMMARY
Accumulating evidence from both preclinical and clinical studies suggests that Twist1 is a pivotal regulator of several forms of renal disease. Twist1 is persistently activated following renal insults, particularly in chronic kidney diseases, and contributes to the renal inflammatory responses, tubular cell transformation programs, and possibly fibroblast activation, all of which are involved in the initiation and progression of kidney diseases.
KEY MESSAGE
This review will specifically focus on Twist1 and outline our understanding of its functions in kidney disorders along with the introduction of Twist2 where pertinent. The thorough knowledge of Twist1's actions in the pathogenesis of kidney diseases should facilitate the development of novel therapeutics for kidney injury.
背景
Twist1是一种含碱性螺旋-环-螺旋结构域的转录因子，通过转录调控多种下游靶基因来调节细胞分化、迁移、增殖、存活及炎症反应。其同源蛋白Twist2与Twist1在结构和功能上有许多相似之处。
总结
临床前和临床研究的越来越多证据表明，Twist1是多种肾脏疾病的关键调节因子。肾脏受到损伤后，尤其是在慢性肾脏病中，Twist1会持续激活，并促进肾脏炎症反应、肾小管细胞转化程序以及可能的成纤维细胞激活，所有这些都参与了肾脏疾病的发生和发展。
关键信息
本综述将特别聚焦于Twist1，并概述我们对其在肾脏疾病中功能的理解，同时在相关处引入Twist2。深入了解Twist1在肾脏疾病发病机制中的作用应有助于开发针对肾脏损伤的新型治疗方法。
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