Allendes Osorio Rodolfo S, Nyström-Persson Johan T, Nojima Yosui, Kosugi Yuji, Mizuguchi Kenji, Natsume-Kitatani Yayoi
Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan.
Lifematics Ltd., Sanshin Hatchobori bldg. 5F, 2-25-10 Hatchobori, Chuo-ku, Tokyo-to, 104-0032, Japan.
Heliyon. 2020 Aug 19;6(8):e04618. doi: 10.1016/j.heliyon.2020.e04618. eCollection 2020 Aug.
Multi-omics analyses, combining transcriptomics, genomics, proteomics, and so on, have led to important insights in many areas of biology and medicine. To support these analyses, software that can handle the difficulties associated with multi-omics datasets is crucial. Here, we describe , a web-based, interactive analysis environment for multi-omics data. Building on Toxygates, a tool previously created to study single-omics data that features interactive clustering, heatmaps, and user data uploads, Panomicon introduces improvements for the storage and handling of additional omics types, as well as tools for the generation and visualization of interaction networks between different types of omics data. Panomicon is a new type of environment for the collaborative study of multi-omics data, both for users uploading data to our server and for groups wishing to host their own deployment of Panomicon. We demonstrate Panomicon's capabilities by revisiting a microRNA-mRNA interaction networks study in a non-small cell lung cancer dataset.
多组学分析结合了转录组学、基因组学、蛋白质组学等，在生物学和医学的许多领域都带来了重要的见解。为支持这些分析，能够处理多组学数据集相关难题的软件至关重要。在此，我们描述了Panomicon，一个用于多组学数据的基于网络的交互式分析环境。基于Toxygates（一个先前创建的用于研究单组学数据的工具，具有交互式聚类、热图和用户数据上传功能），Panomicon对额外组学类型的存储和处理进行了改进，还提供了用于生成和可视化不同类型组学数据之间相互作用网络的工具。Panomicon是一种新型的多组学数据协作研究环境，既适用于将数据上传到我们服务器的用户，也适用于希望自行部署Panomicon的团队。我们通过重新审视一个非小细胞肺癌数据集中的微小RNA - mRNA相互作用网络研究来展示Panomicon的功能。
