Robinson Andrew C, Davidson Yvonne S, Roncaroli Federico, Minshull James, Tinkler Phillip, Horan Michael A, Payton Antony, Pendleton Neil, Mann David M A
Division of Neuroscience & Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, UK.
Manchester Academic Health Science Centre (MAHSC), Manchester, UK.
J Alzheimers Dis Rep. 2020 Jul 23;4(1):281-286. doi: 10.3233/ADR-200203.
While many studies have examined the associations between genotype and mortality, findings have often been conflicting and it remains unclear whether genotype affects longevity. Using selected individuals from the Manchester arm of the Brains for Dementia Research programme and University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age, we investigated relationships between genotype and age at death in both cognitively normal and cognitively impaired individuals. Results indicated that carrying the 4 allele led to a reduced chance in an individual reaching 80+ years and remaining cognitively healthy. Conversely, 2 carriers tended to live longer and remain cognitively normal. These findings add to the evidence that genotype influences longevity, especially in cognitively impaired individuals who carry the 4 allele.
虽然许多研究已经探讨了基因型与死亡率之间的关联，但研究结果往往相互矛盾，基因型是否影响寿命仍不清楚。我们从痴呆症研究项目的曼彻斯特分支以及曼彻斯特大学正常健康老年人认知纵向研究中选取个体，调查了认知正常和认知受损个体的基因型与死亡年龄之间的关系。结果表明，携带4等位基因会降低个体活到80岁以上并保持认知健康的几率。相反，携带2等位基因的个体往往寿命更长且保持认知正常。这些发现进一步证明了基因型会影响寿命，尤其是在携带4等位基因的认知受损个体中。
