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可食用蘑菇中的艾杜烷倍半萜类化合物及其生物活性。

Illudane Sesquiterpenoids from Edible Mushroom and Their Bioactivities.

作者信息

Dai Quan, Zhang Fa-Lei, Du Jiao-Xian, Li Zheng-Hui, Feng Tao, Liu Ji-Kai

机构信息

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, P. R. China.

The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, P. R. China.

出版信息

ACS Omega. 2020 Aug 19;5(34):21961-21967. doi: 10.1021/acsomega.0c03314. eCollection 2020 Sep 1.

DOI:10.1021/acsomega.0c03314
PMID:32905428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469647/
Abstract

To comprehensively understand the chemical constituents of the edible mushroom and their biological functions, a phytochemical separation of the cultural broth of led to the isolation of four new illudane sesquiterpenoids, agrocybins H-K (-), along with 10 known analogues (-). Compounds - were racemates of which and were further separated into single enantiomers as / and /. All new structures with absolute configurations were elucidated on the basis of an extensive spectroscopic analysis and quantum chemistry calculations. Compound possesses a new carbon skeleton that might be derived from the protoilludane backbone. Compounds , , , and show a certain degree of cytotoxicity to five human cancer cell lines. Compound shows a mild inhibitory effect on nitric oxide production with an IC value of 31.4 μM. It is concluded that is rich in illudin derivatives with potential bioactivity prospects, which would make a good material of medicine and food homology.

摘要

为全面了解食用菌的化学成分及其生物学功能，对其培养液进行植物化学分离，得到了四种新的伊利丹倍半萜类化合物，即农霉素H-K（-），以及10种已知类似物（-）。化合物-为外消旋体，其中和进一步拆分为单一对映体/和/。基于广泛的光谱分析和量子化学计算，阐明了所有具有绝对构型的新结构。化合物具有一种可能源自原伊利丹骨架的新碳骨架。化合物、、、和对五种人类癌细胞系表现出一定程度的细胞毒性。化合物对一氧化氮的产生具有轻度抑制作用，IC值为31.4μM。得出结论，富含具有潜在生物活性前景的伊利丹衍生物，这将使其成为药食同源的良好材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/5dbddc4ff7b5/ao0c03314_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/ba69f2d99411/ao0c03314_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/6c3f99898aca/ao0c03314_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/87369584d42c/ao0c03314_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/16418fc39e2a/ao0c03314_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/d6effea1d168/ao0c03314_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/5dbddc4ff7b5/ao0c03314_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/ba69f2d99411/ao0c03314_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/6c3f99898aca/ao0c03314_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/87369584d42c/ao0c03314_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/16418fc39e2a/ao0c03314_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/d6effea1d168/ao0c03314_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5be/7469647/5dbddc4ff7b5/ao0c03314_0006.jpg

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