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减少偏差的非参数寿命密度和风险估计。

Reduced bias nonparametric lifetime density and hazard estimation.

作者信息

Berg Arthur, Politis Dimitris, Suaray Kagba, Zeng Hui

机构信息

Penn State College of Medicine, Division of Biostatistics & Bioinformatics.

University of California, San Diego, Department of Mathematics.

出版信息

Test (Madr). 2020 Sep;29(3):704-727. doi: 10.1007/s11749-019-00677-z. Epub 2019 Aug 17.

DOI:10.1007/s11749-019-00677-z
PMID:32905469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469523/
Abstract

Kernel-based nonparametric hazard rate estimation is considered with a special class of infinite-order kernels that achieves favorable bias and mean square error properties. A fully automatic and adaptive implementation of a density and hazard rate estimator is proposed for randomly right censored data. Careful selection of the bandwidth in the proposed estimators yields estimates that are more efficient in terms of overall mean squared error performance, and in some cases achieves a nearly parametric convergence rate. Additionally, rapidly converging bandwidth estimates are presented for use in second-order kernels to supplement such kernel-based methods in hazard rate estimation. Simulations illustrate the improved accuracy of the proposed estimator against other nonparametric estimators of the density and hazard function. A real data application is also presented on survival data from 13,166 breast carcinoma patients.

摘要

基于核的非参数危险率估计是针对一类特殊的无穷阶核进行考虑的,这类核具有良好的偏差和均方误差性质。针对随机右删失数据,提出了一种密度和危险率估计器的全自动自适应实现方法。在所提出的估计器中仔细选择带宽,可得到在整体均方误差性能方面更有效的估计,并且在某些情况下实现了近乎参数收敛速率。此外,还给出了用于二阶核的快速收敛带宽估计,以补充危险率估计中此类基于核的方法。模拟结果表明,与密度和危险函数的其他非参数估计器相比,所提出的估计器具有更高的精度。还给出了一个关于13166例乳腺癌患者生存数据的实际应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/24acb49ff2ce/nihms-1537682-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/41fb45ded591/nihms-1537682-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/a406a5f3a358/nihms-1537682-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/c3a5c24104ab/nihms-1537682-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/7cbd2cb106ad/nihms-1537682-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/24acb49ff2ce/nihms-1537682-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/41fb45ded591/nihms-1537682-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/a406a5f3a358/nihms-1537682-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/c3a5c24104ab/nihms-1537682-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/7cbd2cb106ad/nihms-1537682-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0549/7469523/24acb49ff2ce/nihms-1537682-f0005.jpg

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本文引用的文献

1
Nonparametric estimation of transition probabilities in the non-Markov illness-death model: A comparative study.非马尔可夫疾病死亡模型中转移概率的非参数估计:一项比较研究。
Biometrics. 2015 Jun;71(2):364-75. doi: 10.1111/biom.12288. Epub 2015 Mar 2.
2
The shape of the hazard function in breast carcinoma: curability of the disease revisited.乳腺癌风险函数的形状:对该疾病可治愈性的重新审视。
Cancer. 1999 Apr 15;85(8):1789-98.
3
Hazard rate estimation under random censoring with varying kernels and bandwidths.在随机删失情况下,采用不同核函数和带宽的风险率估计
Biometrics. 1994 Mar;50(1):61-76.