Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Pediatrics, New Taipei Municipal Tucheng Hospital, Chang Gung Memorial Hospital, Tucheng, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Environ Res. 2020 Dec;191:110123. doi: 10.1016/j.envres.2020.110123. Epub 2020 Sep 6.
Reports on the relationship between prenatal exposure to bisphenol-A (BPA) and the development of childhood allergy have been conflicting. This study aimed to investigate the impact of prenatal BPA exposure on several objective outcomes such as cytokine profile, atopic sensitization, and infant lung function (ILF) tests in addition to clinical allergic symptoms.
A subset of 274 children from the PATCH cohort study with available cord BPA data were followed until 3 years of age. Total and specific IgE level and Toll-like receptor (TLR) stimulated cytokine production were assessed yearly since birth. ILF such as tidal volume, Vmax, airway resistance and compliance were performed at least once before the age of 2 years. Allergic outcome was determined by questionnaires and physician's assessment.
There was significant association between BPA concentration and IgE level in the cord blood (p < 0.01), but the correlation was no longer significant at ages 1 through 3 years. In addition, cord BPA concentration was associated with dysregulated TLR stimulated TNF-α and IL-6 production, but the correlation was significant only at birth. No relationship was found between cord BPA concentration and ILF measurements or allergic symptoms (wheezing, rhino-conjunctivitis, or eczema) throughout early childhood.
Results showed that prenatal exposure to BPA was not associated with increased risk of childhood allergy or impaired ILF. However, with its impact on biomarkers for allergy such as alterations in perinatal cytokine profile and elevated cord IgE level, the potential role of prenatal BPA exposure on the development of allergy cannot be disregarded.
关于产前暴露于双酚 A（BPA）与儿童过敏发展之间的关系，已有报告结果相互矛盾。本研究旨在调查产前 BPA 暴露对几项客观结果的影响，除了临床过敏症状外，这些客观结果还包括细胞因子谱、特应性致敏和婴儿肺功能（ILF）测试。
PATCH 队列研究中有部分 274 名儿童有脐带 BPA 数据，对这些儿童进行随访，直到他们 3 岁。自出生以来，每年评估总 IgE 和特异性 IgE 水平以及 Toll 样受体（TLR）刺激细胞因子的产生。至少在 2 岁之前进行 ILF 测试，如潮气量、Vmax、气道阻力和顺应性。过敏结局通过问卷调查和医生评估来确定。
脐带血中 BPA 浓度与 IgE 水平呈显著相关（p<0.01），但在 1 至 3 岁时，相关性不再显著。此外，脐带 BPA 浓度与 TLR 刺激的 TNF-α和 IL-6 产生失调有关，但这种相关性仅在出生时显著。在整个幼儿期，脐带 BPA 浓度与 ILF 测量或过敏症状（喘息、鼻结膜炎或湿疹）之间没有关系。
结果表明，产前暴露于 BPA 与儿童过敏风险增加或 ILF 受损无关。然而，由于其对过敏生物标志物的影响，如围产期细胞因子谱的改变和脐带 IgE 水平升高，产前 BPA 暴露对过敏发展的潜在作用不容忽视。
