Ashley-Martin Jillian, Dodds Linda, Levy Adrian R, Platt Robert W, Marshall Jean S, Arbuckle Tye E
Interdisciplinary PhD Program, Dalhousie University, IDPhD c/o Faculty of Graduate Studies, Room, 314 H Hicks Building, 6299 South Street, Halifax, NS, Canada B3H 4H6.
Department of Obstetrics & Gynaecology and Paediatrics, Dalhousie University, Perinatal Epidemiology Research Unit, 7th Floor Women's Site, IWK Health Centre, 5980 University Avenue, PO Box 9700, Halifax, NS, Canada B3H 6R8.
Environ Res. 2015 Jul;140:360-8. doi: 10.1016/j.envres.2015.04.010. Epub 2015 Apr 24.
The fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental exposures. Epidemiologists and toxicologists have hypothesized that phthalates, bisphenol A (BPA) and perfluoroalkyl substance have immunotoxic properties. Immunotoxic effects of chemicals may manifest in an altered immune system profile at birth. Immunoglobulin E, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) are integral in the etiology of childhood allergy and detectable at birth. The objective of this study was to determine the association between maternal levels of phthalates, bisphenol A (BPA), and perfluoroalkyl substances and elevated umbilical cord blood levels of IgE, TSLP, and IL-33. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Of these women, 1258 had a singleton, term birth and cord blood sample. A Bayesian hierarchical model was employed to determine associations between log-transformed continuous variables and immune system biomarkers while adjusting for potential confounding from correlated environmental contaminants. Inverse, nonlinear associations were observed between maternal urinary MCPP levels and elevated levels of both IL-33/TSLP and IgE and between maternal urinary BPA levels and elevated levels of IL-33/TSLP. In this primarily urban Canadian population of pregnant women and their newborns, maternal urinary and plasma concentrations of phthalate metabolites, BPA, and perfluoroalkyl substances were not associated with immunotoxic effects that manifest as increased odds of elevated levels of IgE, TSLP or IL-33.
胎儿期是免疫系统发育的关键窗口期，在此期间胎儿对环境暴露的不良影响易感性增强。流行病学家和毒理学家推测，邻苯二甲酸盐、双酚A（BPA）和全氟烷基物质具有免疫毒性。化学物质的免疫毒性作用可能在出生时表现为免疫系统特征的改变。免疫球蛋白E、胸腺基质淋巴细胞生成素（TSLP）和白细胞介素-33（IL-33）在儿童过敏病因中起重要作用，且在出生时可检测到。本研究的目的是确定孕妇体内邻苯二甲酸盐、双酚A（BPA）和全氟烷基物质水平与脐带血中IgE、TSLP和IL-33水平升高之间的关联。本研究利用了环境化学物质母婴研究（MIREC）收集的数据，这是一项对2001名孕妇进行的跨加拿大队列研究。在这些女性中，1258人单胎足月分娩并采集了脐带血样本。采用贝叶斯分层模型来确定对数转换后的连续变量与免疫系统生物标志物之间的关联，同时调整相关环境污染物的潜在混杂因素影响。研究发现，孕妇尿中MCPP水平与IL-33/TSLP和IgE水平升高之间存在反向、非线性关联，孕妇尿中BPA水平与IL-33/TSLP水平升高之间也存在反向、非线性关联。在这个主要为加拿大城市地区的孕妇及其新生儿群体中，孕妇尿和血浆中邻苯二甲酸酯代谢物、BPA和全氟烷基物质的浓度与表现为IgE、TSLP或IL-33水平升高几率增加的免疫毒性作用无关。
