Kiook Baek, Jong-Tae Park, Kyeongmin Kwak
Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, Ansan 15355, Korea.
Toxics. 2021 Nov 4;9(11):291. doi: 10.3390/toxics9110291.
The effects of bisphenol A (BPA) on asthma have been reported in various in vitro, animal, and human epidemiologic studies. However, epidemiological studies on the effects of bisphenol S (BPS) and bisphenol F (BPF), which are substitutes of BPA, on asthma are lacking. The purpose of this study was to identify the association between BPA, BPS, and BPF and asthma. An asthma-related questionnaire; urinary BPA, BPS, BPF; and the possible confounders were analyzed among 922 adolescents aged 12-17 years who participated in the Korean National Environmental Health Survey 2016. In males, urinary BPA, BPS, and BPF did not show a significant relationship with the lifetime prevalence of asthma. In females, urinary BPS was higher in the asthma group ( < 0.01). High urinary BPS showed a significant relationship with a high odds ratio (OR) of lifetime asthma prevalence in the model adjusted for possible confounders ( < 0.05). High urinary BPS was particularly associated with an increase in the OR of asthma diagnosed after the age of 60 months ( < 0.01). Urinary BPS was significantly associated with asthma diagnosis, especially after the age of 60 months, among Korean adolescent females.
双酚A（BPA）对哮喘的影响已在各种体外、动物和人类流行病学研究中有所报道。然而，关于双酚S（BPS）和双酚F（BPF）（BPA的替代品）对哮喘影响的流行病学研究却很缺乏。本研究的目的是确定BPA、BPS和BPF与哮喘之间的关联。在参与2016年韩国国家环境卫生调查的922名12至17岁青少年中，分析了一份与哮喘相关的问卷、尿中的BPA、BPS、BPF以及可能的混杂因素。在男性中，尿中的BPA、BPS和BPF与哮喘的终生患病率未显示出显著关系。在女性中，哮喘组的尿BPS较高（<0.01）。在针对可能的混杂因素进行调整的模型中，高尿BPS与哮喘终生患病率的高比值比（OR）显示出显著关系（<0.05）。高尿BPS尤其与60个月龄后诊断出的哮喘的OR增加有关（<0.01）。在韩国青少年女性中，尿BPS与哮喘诊断显著相关，尤其是在60个月龄之后。
