Rakusiewicz Klaudia, Kanigowska Krystyna, Hautz Wojciech, Ziółkowska Lidia
Department of Ophthalmology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Department of Cardiology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
J Clin Med. 2020 Sep 7;9(9):2882. doi: 10.3390/jcm9092882.
To assess ganglion cell complex (GCC) thickness in children with chronic heart failure (CHF) due to dilated cardiomyopathy (DCM) using optical coherence tomography (OCT).
Sixty eyes of 30 patients with chronic heart failure (CHF) due to dilated cardiomyopathy (DCM) and 60 eyes of 30 age- and sex-matched healthy volunteers (control group) were enrolled. The mean age of the patients and controls was 9.9 ± 3.57 (range 5-17) years and 10.08 ± 3.41 (range 4-16) years, respectively. All patients underwent a complete ophthalmic assessment and OCT imaging using RTVue XR Avanti (Optovue). The following OCT-based parameters were analysed: average ganglion cell complex thickness (avgGCC), superior ganglion cell complex thickness (supGCC), inferior ganglion cell complex thickness (infGCC), global loss of volume (GLV) and focal loss of volume (FLV).
There were no significant differences in avgGCC (98.13 μm vs. 99.96 μm, = 0.21), supGCC (97.17 μm vs. 99.29 μm, = 0.13), infGCC (99.03 μm vs. 100.71 μm, = 0.25), FVL (0.49% vs. 0.4%, = 0.25) and GVL (2.1% vs. 1.3%, = 0.09) between patients with chronic heart failure due to dilated cardiomyopathy and healthy children. There was no correlation between avgGCC, supGCC, infGCC, FLV, GLV and ocular biometry, refractive errors or age. There was no correlation between avgGCC, supGCC, infGCC, FLV, GLV and NT-proBNP or LVEF. There were no significant differences in the studied parameters between the sexes. There were no significant differences in the studied parameters between the left and right eye.
Our study seems to be the first to analyse ganglion cell complex in paediatric patients with dilated cardiomyopathy. We have demonstrated no changes in the ganglion cell complex thickness parameters in children with chronic heart failure due dilated cardiomyopathy, as compared to their healthy peers.
使用光学相干断层扫描（OCT）评估扩张型心肌病（DCM）所致慢性心力衰竭（CHF）患儿的神经节细胞复合体（GCC）厚度。
纳入30例因扩张型心肌病导致慢性心力衰竭患者的60只眼，以及30名年龄和性别匹配的健康志愿者（对照组）的60只眼。患者组和对照组的平均年龄分别为9.9±3.57岁（范围5 - 17岁）和10.08±3.41岁（范围4 - 16岁）。所有患者均接受了全面的眼科评估，并使用RTVue XR Avanti（Optovue）进行OCT成像。分析了以下基于OCT的参数：平均神经节细胞复合体厚度（avgGCC）、上方神经节细胞复合体厚度（supGCC）、下方神经节细胞复合体厚度（infGCC）、总体积损失（GLV）和局灶体积损失（FLV）。
扩张型心肌病所致慢性心力衰竭患者与健康儿童在avgGCC（98.13μm对99.96μm，P = 0.21）、supGCC（97.17μm对99.29μm，P = 0.13）、infGCC（99.03μm对100.71μm，P = 0.25）、FVL（0.49%对0.4%，P = 0.25）和GVL（2.1%对1.3%，P = 0.09）方面均无显著差异。avgGCC、supGCC、infGCC、FLV、GLV与眼生物测量、屈光不正或年龄之间无相关性。avgGCC、supGCC、infGCC、FLV、GLV与NT - proBNP或LVEF之间无相关性。研究参数在性别之间无显著差异。研究参数在左眼和右眼之间无显著差异。
我们的研究似乎是首个分析扩张型心肌病儿科患者神经节细胞复合体的研究。我们已证明，与健康同龄人相比，扩张型心肌病所致慢性心力衰竭患儿的神经节细胞复合体厚度参数无变化。
