Kim Daehyun, Lee Seung Soo, Yoo Woo Young, Moon Hyungwon, Cho Aesin, Park So Yeon, Kim Yoon-Seok, Kim Hyun Ryoung, Lee Hak Jong
Department of Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-744, Korea.
Department of Radiology, Seoul National University Bundang Hospital, 82 Gumi-ro 173, Bundang-gu, Seongnam 13620, Korea.
Pharmaceuticals (Basel). 2020 Sep 7;13(9):235. doi: 10.3390/ph13090235.
Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance the drug half-life while minimizing the associated toxicity. Nevertheless, relying solely on the enhanced half-life and enhanced permeability and retention (EPR) effects has been ineffective, and designing stimulus-sensitive nanoparticles to introduce the precise control of drug release has been desired. In this paper, we introduce a pH-sensitive, reduced albumin nanoparticle in combination with focused ultrasound treatment. Not only did these nanoparticles have superior therapeutic efficacy and toxicity profiles when compared to the free drugs in xenograft mouse models, but we were also able to show that the albumin nanoparticles reported in this paper were more suitable than other types of non-reduced albumin nanoparticles as vehicles for drug delivery. As such, we believe that the albumin nanoparticles presented in this paper with desirable characteristics including the induction of strong anti-tumor response, precise control, and superior safety profiles hold strong potential for preclinical and clinical anticancer therapy.
由于化疗药物常常伴有严重的副作用，现代药物递送的核心课题是使药物在靶部位的定位最大化，同时将药物在非靶部位的非特异性相互作用最小化。为解决这一问题，已开发出生物相容性纳米颗粒，以延长药物半衰期，同时将相关毒性降至最低。然而，单纯依靠延长半衰期以及增强渗透与滞留（EPR）效应并不奏效，因此人们期望设计出对刺激敏感的纳米颗粒，以实现对药物释放的精确控制。在本文中，我们介绍了一种pH敏感的还原型白蛋白纳米颗粒，并结合聚焦超声治疗。与异种移植小鼠模型中的游离药物相比，这些纳米颗粒不仅具有卓越的治疗效果和毒性特征，而且我们还能够证明，本文报道的白蛋白纳米颗粒作为药物递送载体比其他类型的非还原型白蛋白纳米颗粒更合适。因此，我们认为本文所呈现的白蛋白纳米颗粒具有包括诱导强烈抗肿瘤反应、精确控制和卓越安全性等理想特性，在临床前和临床抗癌治疗方面具有巨大潜力。
