Phan Quoc-Hung, Lai You-Rui, Xiao Wei-Zhe, Pham Thi-Thu-Hien, Lien Chi-Hsiang
Opt Express. 2020 Aug 17;28(17):24889-24899. doi: 10.1364/OE.400721.
A surface plasmon resonance (SPR) prism coupler is proposed for the high-resolution non-invasive (NI) measurement of the circular birefringence (CB) properties of turbid media. The feasibility of the proposed device is demonstrated by means of numerical simulations. It is shown that the SPR sensor enables the CB properties to be detected with a resolution of up to 8.9 × 10 RIU (refractive index units) for refractive indices in the range of 1.3∼1.4. Moreover, for tissue phantom solutions containing 2% lipofundin, the device has a detection limit of 3.72 mg/dL. This resolution performance satisfies the detection limit of 10 mg/dL stipulated by the U.S FDA for point-of-care glucose monitoring devices. Thus, the proposed SPR sensor has significant potential for NI glucose sensing in such applications as diabetes detection and management.
提出了一种表面等离子体共振（SPR）棱镜耦合器，用于对混浊介质的圆双折射（CB）特性进行高分辨率非侵入式（NI）测量。通过数值模拟证明了所提出装置的可行性。结果表明，对于1.3至1.4范围内的折射率，SPR传感器能够以高达8.9×10 RIU（折射率单位）的分辨率检测CB特性。此外，对于含有2%脂肪乳剂的组织模拟溶液，该装置的检测限为3.72 mg/dL。这种分辨率性能满足了美国食品药品监督管理局（FDA）规定的即时检测血糖监测设备10 mg/dL的检测限。因此，所提出的SPR传感器在糖尿病检测和管理等应用中的非侵入式葡萄糖传感方面具有巨大潜力。
