Analysis of Correlation between the Seven Important (. ) Virulence Factors and Drug Resistance in Patients with Gastritis.

The aim of this study is to evaluate the association between seven important . virulence factors and antibiotic resistance in patients with gastritis. . strains isolated from 33 patients with gastritis were examined. Antimicrobial susceptibilities were tested by GenoType® HelicoDR (Hain Life Science, Germany) test kit and RT-PCR. The virulence-factors were determined using conventional PCR. 39% of patients were resistant for clarithromycin and 27% of patients were resistant for fluoroquinolone. 15% of patients were resistant to both clarithromycin and fluoroquinolone. The . genotype was the most frequent allelic combination. Patients were possessed the , (6.1%); , (6.1%); , (15.1%); and , (3.0%) genotypes. 94% of patients with gastritis were positive for . gene. Also, there were no gene-positive gastritis patients. There was no significant correlation between the , , , , , , , , virulence genes, clarithromycin, and fluoroquinolone resistance. Herein, we report that the relationship between the . gene and gastritis. Although we found a correlation between . virulence factor and clinical outcome, there is a need for further studies to enlighten the relation between . virulence genes and antibiotic resistance.