Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London (UCL), London, UK.
Cancer Prevention Group, School of Cancer and Pharmaceutical Sciences, King's College London (KCL), London, UK.
Psychooncology. 2021 Jan;30(1):84-92. doi: 10.1002/pon.5540. Epub 2020 Sep 21.
To explore reasons for variations in anxiety in women testing positive for human papillomavirus (HPV) with normal cytology at routine HPV primary cervical cancer screening.
In-depth interviews were conducted with 30 women who had tested HPV-positive with normal cytology, including 15 with low-to-normal anxiety and 15 with high anxiety. Data were analysed using Framework Analysis to compare themes between low and high anxiety groups.
Several HPV-related themes were shared across anxiety groups, but only highly anxious women expressed fear and worry, fatalistic cognitions about cancer, fertility-related cognitions, adverse physiological responses and changes in health behaviour(s). In comparison to those with low anxiety, women with high anxiety more strongly voiced cognitions about the 12-month wait for follow-up screening, relationship infidelity, a lower internal locus of control and HPV-related symptom attributions.
Receiving an HPV-positive with normal cytology result related to various emotional, cognitive, behavioural and physiological responses; some of which were specific to, or more pronounced in, women with high anxiety. If our observations are confirmed in hypothesis-driven quantitative studies, the identification of distinct themes relevant to women experiencing high anxiety can inform targeted patient communications and HPV primary screening implementation policy.
探讨在常规人乳头瘤病毒（HPV）初级宫颈癌筛查中细胞学正常但 HPV 阳性的女性出现焦虑差异的原因。
对 30 名细胞学正常但 HPV 阳性的女性进行深入访谈，其中包括 15 名低中度焦虑和 15 名高度焦虑的女性。使用框架分析对数据进行分析，以比较低焦虑和高焦虑组之间的主题。
几个与 HPV 相关的主题在焦虑组中是共同的，但只有高度焦虑的女性表达了恐惧和担忧、对癌症的宿命论认知、与生育相关的认知、不良的生理反应和健康行为的改变。与低焦虑的女性相比，高焦虑的女性更强烈地表达了对 12 个月随访筛查的等待、关系不忠、较低的内部控制感以及与 HPV 相关的症状归因的认知。
细胞学正常但 HPV 阳性的结果与各种情绪、认知、行为和生理反应有关；其中一些在高度焦虑的女性中更为明显或更为突出。如果我们的观察在假设驱动的定量研究中得到证实，那么确定与高度焦虑女性相关的独特主题可以为有针对性的患者沟通和 HPV 初级筛查实施政策提供信息。
