钙、生物能量学与帕金森病。
Calcium, Bioenergetics, and Parkinson's Disease.
机构信息
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
出版信息
Cells. 2020 Sep 8;9(9):2045. doi: 10.3390/cells9092045.
Abstract
Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.
摘要
黑质（SN）多巴胺能（DAergic）神经元的退化是帕金森病（PD）核心运动缺陷的原因。这些神经元是自主起搏器，具有与基础线粒体氧化剂应激和周转率相关的大胞质 Ca 振荡。本综述探讨了 Ca 振荡的起源及其在控制线粒体呼吸、生物能学和线粒体氧化剂应激中的作用。
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