Department of Naturopathic Medicine, Endeavour College of Natural Health, Sydney 2000, Australia.
WholMed Consultancy, Sydney 2000, Australia.
Molecules. 2020 Sep 8;25(18):4099. doi: 10.3390/molecules25184099.
Olive leaf extract (OLE), prepared from the fresh or dried leaves of L., is generating interest as a cardiovascular and metabolic disease risk modifier. Positive effects for the leaf extract and its key phytochemical constituents have been reported on blood pressure, respiratory infections, inflammation, and insulin resistance. A variety of OLE products are available both over-the-counter and for professional dispensing. The aim of this research was to quantitatively explore the phytochemical profile of different OLE products on the Australian market. Ten OLE products available on the Australian market (five over-the-counter products and five products for professional compounding and dispensing) were quantitatively analyzed for oleuropein, hydroxytyrosol, oleacein, oleocanthal, total biophenols, maslinic acid, and oleanolic acid, using high-performance liquid chromatography (HPLC). Substantial variation in oleuropein and hydroxytyrosol levels was noted between extracts, with a trend towards higher oleuropein and lower hydroxytyrosol levels being noted in products produced using the fresh olive leaf as opposed to dry olive leaf. These results suggest that OLE products on the Australian market vary substantially in their phytochemical profiles. Products for professional compounding and dispensing in many cases contained less oleuropein than over-the-counter products, but more hydroxytyrosol and comparable total biophenol levels.
橄榄叶提取物（OLE），由新鲜或干燥的橄榄叶制成，作为心血管和代谢疾病风险调节剂引起了人们的兴趣。该叶提取物及其关键植物化学成分已被报道对血压、呼吸道感染、炎症和胰岛素抵抗具有积极作用。各种 OLE 产品既有非处方产品，也有专业配药产品。本研究旨在定量研究澳大利亚市场上不同 OLE 产品的植物化学成分谱。定量分析了澳大利亚市场上的 10 种 OLE 产品（5 种非处方产品和 5 种用于专业配制和配药的产品）中的橄榄苦苷、羟基酪醇、橄榄苦苷、酪醇、总生物酚、齐墩果酸和熊果酸，使用高效液相色谱法（HPLC）。提取物中橄榄苦苷和羟基酪醇水平存在明显差异，使用新鲜橄榄叶制成的产品中橄榄苦苷水平较高，而羟基酪醇水平较低。这些结果表明，澳大利亚市场上的 OLE 产品在植物化学成分谱方面存在很大差异。许多专业配制和配药产品中的橄榄苦苷含量低于非处方产品，但羟基酪醇和总生物酚水平相当。
