EBTNA-Lab, Via Delle Maioliche, 57/G, 38068, Rovereto, TN, Italy; MAGI's Lab, Via Delle Maioliche, 57/D, 38068, Rovereto, TN, Italy; MAGI Euregio, Via Maso della Pieve, 60/A, 39100, Bolzano, Italy.
Allama Iqbal Open University, Sector H-8, 44000, Islamabad, Pakistan.
J Biotechnol. 2020 Feb 10;309:29-33. doi: 10.1016/j.jbiotec.2019.12.016. Epub 2019 Dec 26.
Hydroxytyrosol is a phenolic phytochemical with antioxidant properties in vitro. It is a natural compound that can be found in olive leaves and oil. The main dietary source of hydroxytyrosol is extra virgin olive oil. Due to its bioavailability, chemical properties and easy formulation along with its lack of toxicity, hydroxytyrosol is considered an excellent food supplement by the nutraceutical and food industries. The purpose of this review is to discuss the potential therapeutic effects of hydroxytyrosol in vivo. To do so, we conducted an electronic search in PubMed and other literature databases using "hydroxytyrosol", "beneficial effect/s", "pharmacology" as key-words. From this search, we found that hydroxytyrosol has anti-inflammatory, anti-tumor, antiviral, antibacterial and antifungal properties. Hydroxytyrosol also improves endothelial dysfunction, decreases oxidative stress, and is neuro- and cardio-protective. Due to all these biological properties, hydroxytyrosol is currently the most actively investigated natural phenol. The evidence presented in this review suggests that hydroxytyrosol has great pharmacological potential.
羟基酪醇是一种具有体外抗氧化特性的酚类植物化学物质。它是一种天然化合物，存在于橄榄叶和油中。羟基酪醇的主要膳食来源是特级初榨橄榄油。由于其生物利用度、化学性质和易于配方以及缺乏毒性，羟基酪醇被营养保健品和食品行业视为一种极好的食品补充剂。本综述的目的是讨论羟基酪醇在体内的潜在治疗作用。为此，我们在 PubMed 和其他文献数据库中使用“羟基酪醇”、“有益作用/效果”、“药理学”作为关键字进行了电子搜索。从这次搜索中，我们发现羟基酪醇具有抗炎、抗肿瘤、抗病毒、抗菌和抗真菌的特性。羟基酪醇还能改善内皮功能障碍、降低氧化应激，具有神经和心脏保护作用。由于所有这些生物学特性，羟基酪醇目前是最受关注的天然酚类化合物。本综述中提出的证据表明，羟基酪醇具有巨大的药理学潜力。
