Marcos-Tejedor Felix, González-García Pablo, Mayordomo Raquel
Facultad de Ciencias de la Salud, Universidad de Castilla la Mancha, Talavera de la Reina, Toledo, España; Grupo de Investigación DEDAP de la Universidad de Extremadura.
Centro Universitario de Plasencia, Universidad de Extremadura, Plasencia, Cáceres, España; Grupo de Investigación DEDAP de la Universidad de Extremadura.
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Sep 7. doi: 10.1016/j.eimc.2020.06.013.
Onychomycosis is the main cause of nail alteration. Hepatotoxicity, interference and low adherence to pharmacological treatment are associated. Therefore, our objective was to assess the in vitro effectiveness of tea tree essential oil (less harmful) against main causative agents of these infections.
Trichophyton rubrum and Trichophyton mentagrophytes were isolated and inoculated at a concentration of 3x10 CFU / mL in potato agar dextrose and tea tree essential oil at different concentrations to assess its effect by counting colony forming units and radial growth.
Trichophyton rubrum growth inhibition was obtained at concentrations higher than 0.04% of the essential tea tree oil (p = 0.004). In the case of Trichophyton mentagrophytes, inhibition was obtained at 0.02% (p = 0.017), and even complete inhibition at a final concentration of the oil at 0.07%.
Tea tree essential oil inhibits the in vitro growth of the fungus and may be a less harmful alternative to the onychomycosis treatment.
甲癣是指甲病变的主要原因。肝毒性、干扰作用以及对药物治疗的低依从性与之相关。因此，我们的目标是评估茶树精油（危害较小）对这些感染的主要病原体的体外有效性。
分离红色毛癣菌和须癣毛癣菌，并以3×10 CFU / mL的浓度接种于马铃薯葡萄糖琼脂中，同时加入不同浓度的茶树精油，通过计数菌落形成单位和测量径向生长来评估其效果。
当茶树精油浓度高于0.04%时，红色毛癣菌的生长受到抑制（p = 0.004）。对于须癣毛癣菌，在0.02%时生长受到抑制（p = 0.017），在精油终浓度为0.07%时甚至完全抑制。
茶树精油可抑制真菌的体外生长，可能是甲癣治疗中危害较小的替代方法。
