体外茶树油的增溶作用及对甲真菌病抗真菌作用的初步结果。
Solubilization in vitro of tea tree oil and first results of antifungal effect in onychomycosis.
机构信息
Facultad de Ciencias de la Salud, Universidad de Castilla la Mancha, Talavera de la Reina, Toledo, Spain; Grupo de Investigación DEDAP de la Universidad de Extremadura.
Centro Universitario de Plasencia, Universidad de Extremadura, Plasencia, Cáceres, Spain; Grupo de Investigación DEDAP de la Universidad de Extremadura.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Oct;39(8):395-398. doi: 10.1016/j.eimce.2021.07.001. Epub 2021 Jul 30.
INTRODUCTION
Onychomycosis is the main cause of nail alteration. Hepatotoxicity, interference and low adherence to pharmacological treatment are associated. Therefore, our objective was to assess the in vitro effectiveness of tea tree essential oil (less harmful) against main causative agents of these infections.
MATERIAL AND METHODS
Thrichophyton rubrum and Thrichophyton mentagrophytes were isolated and inoculated at a concentration of 3 × 10 CFU/mL in potato agar dextrose and tea tree essential oil at different concentrations to assess its effect by counting colony forming units and radial growth.
RESULTS
Trichophyton rubrum growth inhibition was obtained at concentrations higher than 0.04% of the essential tea tree oil (p = 0.004). In the case of Thrichophyton mentagrophytes, inhibition was obtained at 0.02% (p = 0.017), and even complete inhibition at a final concentration of the oil at 0.07%.
CONCLUSIONS
Tea tree essential oil inhibits the in vitro growth of the fungus and may be a less harmful alternative to the onychomycosis treatment.
简介
甲真菌病是指甲改变的主要原因。其与肝毒性、药物干扰和低药物依从性有关。因此，我们的目的是评估茶树油（危害较小）对这些感染的主要病原体的体外有效性。
材料和方法
红色毛癣菌和须癣毛癣菌在马铃薯葡萄糖琼脂中以 3×10 CFU/mL 的浓度分离和接种，并在不同浓度下用茶树精油评估其效果，通过计算集落形成单位和放射状生长来评估。
结果
红色毛癣菌的生长抑制在茶树精油浓度高于 0.04%时获得（p=0.004）。对于须癣毛癣菌，在 0.02%（p=0.017）时获得抑制，甚至在油的最终浓度为 0.07%时完全抑制。
结论
茶树精油抑制真菌的体外生长，可能是治疗甲真菌病的一种危害较小的替代方法。
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