血清吲哚硫酸酯作为冠状动脉疾病主动脉动脉僵硬的潜在生物标志物。

Serum indoxyl sulfate as a potential biomarker of aortic arterial stiffness in coronary artery disease.

机构信息

Ph. D. Program in Pharmacology and Toxicology, Department of Medicine, School of Medicine, Tzu Chi University, Hualien, 97004, Taiwan; Department of Pharmacology, Tzu Chi University, Hualien, 97004, Taiwan.

Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 97004, Taiwan; School of Medicine, Tzu Chi University, Hualien, 97004, Taiwan.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Nov 27;30(12):2320-2327. doi: 10.1016/j.numecd.2020.07.035. Epub 2020 Jul 31.

DOI:10.1016/j.numecd.2020.07.035

PMID:32912784

Abstract

BACKGROUND AND AIMS

Indoxyl sulfate (IS), a dietary tryptophan metabolite, acts as a cardiotoxin and uremic toxin. High IS levels are associated with chronic kidney disease and cardiovascular diseases. This study investigated the association between serum IS levels and aortic arterial stiffness (AAS) in coronary artery disease (CAD) patients.

METHODS AND RESULTS

The carotid-femoral pulse wave velocity (cfPWV) was measured by the SphygmoCor system and patients with values of >10 m/s were classified in the AAS group. The baseline characteristics were recorded and measured (including biochemical and clinical data). Serum IS levels were determined using liquid chromatography-mass spectrometry. AAS occurred in 50 (34.7%) of 144 patients with CAD. They were older, had higher IS levels and percentages of diabetes, systolic blood pressure, blood urea nitrogen, and creatinine but lower estimated glomerular filtration rates. The IS level and older age significantly correlated with AAS [odds ratio (OR) = 3.834, p = 0.031; OR = 1.095, p = 0.002, respectively]. Furthermore, the serum IS level (β = 0.167, adjusted R change: 0.026, p = 0.027) had a significant positive correlation with cfPWV.

CONCLUSIONS

Taken together, higher serum IS levels are potential independent biomarkers for AAS in patients with CAD. Therefore, early checking of serum IS levels may help prevent CAD progression and have clinical implications in the near future.

摘要

背景与目的

硫酸吲哚酚（IS）是膳食色氨酸的代谢产物，具有心脏毒素和尿毒素的作用。高水平的 IS 与慢性肾脏病和心血管疾病相关。本研究旨在探讨冠心病患者血清 IS 水平与主动脉动脉僵硬度（AAS）之间的关系。

方法和结果

采用 SphygmoCor 系统测量颈股脉搏波速度（cfPWV），将 cfPWV 值>10 m/s 的患者归入 AAS 组。记录并测量基线特征（包括生化和临床数据）。采用液相色谱-质谱法测定血清 IS 水平。在 144 例冠心病患者中，50 例（34.7%）发生 AAS。与无 AAS 组相比，AAS 组患者年龄较大，IS 水平和糖尿病、收缩压、血尿素氮、肌酐的百分比较高，估算肾小球滤过率较低。IS 水平和年龄与 AAS 显著相关[比值比（OR）=3.834，p=0.031；OR=1.095，p=0.002]。此外，血清 IS 水平（β=0.167，调整 R 变化：0.026，p=0.027）与 cfPWV 呈显著正相关。