Jhan Jin-You, Lin Jian-Hong, Yang Kun-Ta, Hsu Bang-Gee, Chang Jui-Chih
Division of Cardiovascular Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Institute of Medical Science, Tzu Chi University, Hualien, Taiwan.
Sci Rep. 2025 Jul 1;15(1):21890. doi: 10.1038/s41598-025-08181-1.
In the patients receiving coronary artery bypass grafting (CABG), arterial stiffness is an independent predictor of disease-related mortality. Higher serum levels of big endothelin-1 (BigET-1) are associated with arterial stiffness. The present study aimed to determine the association between serum BigET-1 levels and arterial stiffness in patients undergoing CABG. A total of 90 patients undergoing CABG were enrolled in the study. Serum levels of BigET-1 are examined with a commercial sandwich enzyme immunoassay. If carotid-femoral pulse wave velocity (cfPWV) > 10 m/s, arterial stiffness is diagnosed. In the study cohort, 30 (33.3%) patients with arterial stiffness were older and had lower body mass index, higher rates of diabetes mellitus and hypertension, higher systolic and diastolic blood pressures, and higher serum BigET-1 levels compared to the controls. Multivariable logistic regression analysis revealed that serum BigET-1 > 1 pg/mL was an independent predictor of arterial stiffness (odds ratio 17.492, 95% confidence interval 2.728-112.147, p = 0.003). Multivariable linear regression analysis revealed that cfPWV significantly correlated with age (β = 0.238, adjusted R change = 0.043, p = 0.004), systolic blood pressure (β = 0.251, adjusted R change = 0.102, p = 0.002), and BigET-1 level (β = 0.533, adjusted R change = 0.387, p < 0.001). Increased serum BigET-1 levels were associated with arterial stiffness in patients undergoing CABG.
在接受冠状动脉旁路移植术（CABG）的患者中，动脉僵硬度是疾病相关死亡率的独立预测因素。血清大内皮素-1（BigET-1）水平升高与动脉僵硬度相关。本研究旨在确定接受CABG患者的血清BigET-1水平与动脉僵硬度之间的关联。共有90例接受CABG的患者纳入本研究。采用商用夹心酶免疫测定法检测血清BigET-1水平。如果颈股脉搏波速度（cfPWV）>10 m/s，则诊断为动脉僵硬度。在研究队列中，与对照组相比，30例（33.3%）有动脉僵硬度的患者年龄更大、体重指数更低、糖尿病和高血压发生率更高、收缩压和舒张压更高，血清BigET-1水平也更高。多变量逻辑回归分析显示，血清BigET-1>1 pg/mL是动脉僵硬度的独立预测因素（比值比17.492，95%置信区间2.728-112.147，p = 0.003）。多变量线性回归分析显示，cfPWV与年龄（β = 0.238，调整后R变化 = 0.043，p = 0.004）、收缩压（β = 0.251，调整后R变化 = 0.102，p = 0.002）和BigET-1水平（β = 0.533，调整后R变化 = 0.387，p < 0.001）显著相关。接受CABG患者血清BigET-1水平升高与动脉僵硬度相关。
