Department of Medicine, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
Department of Cardiothoracic and Vascular Surgery, Chang-Gung Memorial Hospital, Linkou Medical Centre, 5 Fu-Shing Street, Kwei-Shan, Taoyuan, 333, Taiwan.
Sci Rep. 2020 Sep 10;10(1):14883. doi: 10.1038/s41598-020-71961-4.
This retrospective study aimed to clarify the short-term and mid-term outcomes of and prognostic factors for patients who underwent surgical repair for uncomplicated acute type A aortic dissection (ATAAD). Between January 2007 and June 2019, 603 consecutive patients underwent ATAAD repair at our institution. According to patients' preoperative presentations and imaging studies, uncomplicated ATAAD was found in 276 (45.8%) patients by excluding preoperative complicated factors. Patients with uncomplicated ATAAD were classified into the survivor (n = 243) and non-survivor (n = 33) groups. Clinical features, surgical information, and postoperative complications were compared. Three-year survival and freedom from reoperation rates for survivors were analyzed using the Kaplan-Meier actuarial method. The in-hospital surgical mortality rate of uncomplicated ATAAD patients was 11.9%. The non-survivor group had a higher rate of postoperative malperfusion-related complications, and a multivariate analysis revealed that repeat surgery, retrograde cerebral perfusion, and intraoperative extracorporeal membrane oxygenation support were predictors of in-hospital mortality. In the survivor group, 3-year cumulative survival and freedom from aortic reoperation rates were 89.6% (95% confidence interval [CI] 84.8-92.9%) and 83.1% (95% CI 76.8-87.7%), respectively. In conclusion, uncomplicated and complicated ATAAD rates were similar; the short-term and mid-term surgical outcomes in patients with uncomplicated ATAAD were generally acceptable.
本回顾性研究旨在阐明行手术修复的单纯急性 A 型主动脉夹层(ATAAD)患者的短期和中期结果及预后因素。2007 年 1 月至 2019 年 6 月期间,我院对 603 例连续 ATAAD 患者进行了手术修复。根据患者术前表现和影像学研究,排除术前复杂因素后,276 例(45.8%)患者为单纯 ATAAD。将单纯 ATAAD 患者分为存活者(n=243)和非存活者(n=33)。比较两组患者的临床特征、手术信息和术后并发症。采用 Kaplan-Meier 生存分析法分析存活者的 3 年生存率和免于再次手术率。单纯 ATAAD 患者院内手术死亡率为 11.9%。非存活者术后出现灌注不良相关并发症的比例较高,多因素分析显示,再次手术、逆行性脑灌注和术中体外膜肺氧合支持是院内死亡的预测因素。在存活者中,3 年累积生存率和免于主动脉再次手术率分别为 89.6%(95%可信区间[CI]:84.8-92.9%)和 83.1%(95%CI:76.8-87.7%)。总之,单纯型和复杂型 ATAAD 发生率相似;单纯型 ATAAD 患者的短期和中期手术结果通常可接受。