慢性阻塞性肺疾病与昼夜节律基因多态性之间的关联分析
Association analysis between chronic obstructive pulmonary disease and polymorphisms in circadian genes.
作者信息
Chen Guo, Zhang Jingwei, Zhang Lijuan, Xiong Xuan, Yu Dongke, Zhang Yuan
机构信息
Department of Geriatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Cheng Du, China.
Department of Laboratory Medicine, Chengdu Second People's Hospital, Cheng Du, China.
出版信息
PeerJ. 2020 Aug 27;8:e9806. doi: 10.7717/peerj.9806. eCollection 2020.
BACKGROUND
Circadian genes have been suggested to play an important role in lung pathology. However, it remains unknown whether polymorphisms of these genes are associated with chronic obstructive pulmonary disease (COPD). Here, we aimed to investigate the association of circadian genes polymorphisms with COPD in a case-control study of 477 COPD patient and 323 control Han Chinese persons.
METHODS
Genotyping assays were carried out for nine single nucleotide polymorphisms (SNPs) from five circadian genes (, , , and ) that were previously identified in lung pathology. Age, sex, BMI and smoking status and comorbidities were recorded for all subjects.
RESULTS
No significant association was found in all SNP sites in overall subjects and no significant difference was found in age, sex, smoking status stratification analysis.
DISCUSSION
The findings of this investigation indicated the effect of circadian genes polymorphisms on COPD susceptibility may only be small and possibly dependent on the subject factors, such as age and sex.
背景
昼夜节律基因被认为在肺部病理中起重要作用。然而，这些基因的多态性是否与慢性阻塞性肺疾病（COPD）相关仍不清楚。在此，我们旨在通过一项对477例COPD患者和323例对照汉族人群的病例对照研究，调查昼夜节律基因多态性与COPD的关联。
方法
对先前在肺部病理中鉴定出的来自五个昼夜节律基因（，，，和）的九个单核苷酸多态性（SNP）进行基因分型检测。记录所有受试者的年龄、性别、体重指数、吸烟状况和合并症。
结果
在所有受试者的所有SNP位点均未发现显著关联，在年龄、性别、吸烟状况分层分析中也未发现显著差异。
讨论
本研究结果表明，昼夜节律基因多态性对COPD易感性的影响可能很小，并且可能取决于年龄和性别等个体因素。
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