Division of Cell and Molecular Biology, Post Graduate & Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Kerala, India.
Recent Pat Anticancer Drug Discov. 2020;15(3):188-199. doi: 10.2174/1574892815666200910164641.
Breast cancer is the predominant form of cancer in women; various cellular pathways are involved in the initiation and progression of breast cancer. Among the various types of breast cancer that differ in their growth factor receptor status, PI3K/Akt signaling is a common pathway where all these converge. Thus, the PI3K signaling is of great interest as a target for breast cancer prevention; however, it is less explored.
The present review is aimed to provide a concise outline of the role of PI3K/Akt/mTOR pathway in breast carcinogenesis and its progression events, including metastasis, drug resistance and stemness. The review emphasizes the role of natural and synthetic inhibitors of PI3K/Akt/m- TOR pathway in breast cancer prevention.
The data were obtained from PubMed/Medline databases, Scopus and Google patent literature.
PI3K/Akt/mTOR signaling plays an important role in human breast carcinogenesis; it acts on the initiation and progression events associated with it. Numerous molecules have been isolated and identified as promising drug candidates by targeting the signaling pathway. Results from clinical studies confirm their application in the treatment of human breast cancer alone and in combination with classical chemotherapeutics as well as monoclonal antibodies.
PI3K/mTOR signaling blockers have evolved as promising anticancer agents by interfering breast cancer development and progression at various stages. Natural products and bioactive components are emerging as novel inhibitors of PI3K signaling and more research in this area may yield numerous drug candidates.
乳腺癌是女性最常见的癌症类型；各种细胞途径参与乳腺癌的发生和发展。在不同生长因子受体状态的各种乳腺癌类型中，PI3K/Akt 信号通路是一个共同的途径，所有这些途径都汇聚于此。因此，PI3K 信号通路作为乳腺癌预防的靶点非常重要；然而，它的研究还不够深入。
本综述旨在提供 PI3K/Akt/mTOR 通路在乳腺癌发生和进展事件中的简要概述，包括转移、耐药性和干性。本综述强调了 PI3K/Akt/mTOR 通路的天然和合成抑制剂在乳腺癌预防中的作用。
数据来自 PubMed/Medline 数据库、Scopus 和 Google 专利文献。
PI3K/Akt/mTOR 信号通路在人类乳腺癌发生中起重要作用；它作用于与之相关的起始和进展事件。已经分离和鉴定了许多分子，它们作为有前途的药物候选物，通过靶向信号通路发挥作用。来自临床研究的结果证实了它们单独应用于治疗人类乳腺癌以及与经典化疗药物和单克隆抗体联合应用的效果。
PI3K/mTOR 信号通路抑制剂通过干扰乳腺癌在各个阶段的发展和进展，已成为有前途的抗癌药物。天然产物和生物活性成分正在成为 PI3K 信号的新型抑制剂，该领域的更多研究可能会产生许多药物候选物。
