Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Endocrinology Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314001, China.
Endocr Metab Immune Disord Drug Targets. 2021;21(6):971-979. doi: 10.2174/1871530320666200910105612.
Berberine (BBR) is a botanic alkaloid extracted from Coptis chinensis (Huanglian), which has various properties, compassing anti-hyperglycemia, anti-obesity, anti-inflammation, and improves insulin resistance, etc. Several researches have confirmed that BBR has effective actions in treating glycolipid metabolic abnormalities. BBR is also beneficial in regulating intestinal flora. Metabolic diseases are strongly associated with metabolic disorders, which are growing in the population and dramatically impacting human health, which also have been considered as a leading cause of diseases and death globally. This review is to evaluate the metabolic properties of BBR, and its potential application to the treatment of metabolic diseases by its effective actions on metabolic disorders.
小檗碱（BBR）是从黄连中提取的一种植物生物碱，具有多种特性，包括抗高血糖、抗肥胖、抗炎和改善胰岛素抵抗等。多项研究证实，BBR 对治疗糖脂代谢异常具有有效作用。BBR 还有益于调节肠道菌群。代谢性疾病与代谢紊乱密切相关，代谢紊乱在人群中日益增多，严重影响人类健康，也被认为是全球疾病和死亡的主要原因。本综述旨在评估 BBR 的代谢特性，以及通过其对代谢紊乱的有效作用，将其潜在应用于代谢性疾病的治疗。
