Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China; The Academy of Integrative Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Department of Pharmacy, Neuromed Campus, Kepler University Hospital, Linz 4020, Austria.
Biomed Pharmacother. 2021 Jun;138:111468. doi: 10.1016/j.biopha.2021.111468. Epub 2021 Mar 16.
For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they are also prone to metabolic syndrome (MS) and insulin resistance (IR). As an isoquinoline alkaloid, Berberine (BBR) is the main effective component of Coptis. BBR, as a multi-target, multi-path plant extract, can interfere with the development of PCOS and relate to pathological process from many aspects, with less adverse reactions. It is mentioned in this review that BBR can alleviate IR, reduce the level of serum androgen, regulate lipid metabolism and moderate chronic inflammation. BBR is often used in combination with metformin, compound cyproterone (CPA) and other drugs, in order to achieve better therapeutic effect on PCOS.
对于育龄妇女来说，多囊卵巢综合征（PCOS）并不是一种罕见的异质性内分泌紊乱和代谢功能障碍。月经问题、高雄激素血症、多囊卵巢（PCO）和不孕常常影响这些女性，而且她们也容易患代谢综合征（MS）和胰岛素抵抗（IR）。小檗碱（BBR）作为一种异喹啉生物碱，是黄连的主要有效成分。BBR 作为一种多靶点、多途径的植物提取物，可以干扰 PCOS 的发展，并从多个方面与病理过程相关，不良反应较少。本综述提到，BBR 可以减轻胰岛素抵抗，降低血清雄激素水平，调节脂代谢，适度缓解慢性炎症。BBR 常与二甲双胍、复方环丙孕酮（CPA）等药物联合使用，以达到对 PCOS 更好的治疗效果。
