从实验室药物重用到发现 COVID-19 药物的几率有多大？
What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
机构信息
Structural Genomics Consortium, University of Toronto, 101 College Street, Seventh Floor, South Tower, Toronto, Canada M5G 1L6.
出版信息
J Chem Inf Model. 2020 Dec 28;60(12):5727-5729. doi: 10.1021/acs.jcim.0c00861. Epub 2020 Sep 11.
Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.
大规模的药物重新定位（或重新定位）活动正在试图寻找针对 COVID-19 的潜在抗病毒治疗方法。许多方法涉及在先前在人体中被证明安全的化合物库中进行实验或虚拟筛选——“旧药物”。在其他许多疾病的 20 年努力中，从未有过一个新的治疗假设源自于实验室中对旧药物的筛选，从而导致该药物被批准用于新的适应症。
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