Department of Obstetric, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Department of Obstetric, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Placenta. 2020 Nov;101:39-44. doi: 10.1016/j.placenta.2020.08.023. Epub 2020 Sep 3.
In this retrospective study, we investigated whether first trimester serum placental growth factor (PIGF) differed amongst pregnancies with placenta previa-accreta and non-adherent placenta previa and healthy pregnancies.
In 1 January 2017-30 September 2019, a total of 177 pregnant females were included in the study, as follows: 35 cases of placenta previa-accreta, 30 cases of non-adherent placenta previa, and 112 cases of age and BMI-matched, healthy pregnant controls. PIGF multiples of the median (MoM) were acquired from laboratory data files. The predictor of placenta accreta was analyzed by using multiple logistic regression analysis.
PIGF MoM of placenta previa-accreta group was significantly higher than those of the non-adherent placenta previa group and control group (p = 0.0098 < 0.01, p = 0.0002 < 0.01). Serum PIGF was found to be significantly positively associated with placenta accreta after adjusted gestational week at time of blood sampling, BMI, and age (OR: 4.83; 95% CI: 1.91-12.24；p = 0.0009 < 0.01). In addition, previous cesarean section history (OR: 2.75; 95% CI: 1.23-6.17; p = 0.014 < 0.05) and smoking (OR: 9.17; 95% CI: 1.69-49.62; p = 0.010 < 0.05) were also significantly associated with placenta accreta.
Increased first trimester serum PIGF was significantly positively associated with placenta accreta, suggesting that the potential role of PIGF in identifying pregnancies at high risk for placenta accreta. Previous cesarean section history and smoking may be the risk factors for accreta in placenta previa patients.
在这项回顾性研究中，我们调查了前置胎盘伴胎盘植入和非粘连性前置胎盘与健康妊娠的孕妇在妊娠早期血清胎盘生长因子（PIGF）是否存在差异。
在 2017 年 1 月 1 日至 2019 年 9 月 30 日期间，共纳入 177 例孕妇，包括 35 例前置胎盘伴胎盘植入、30 例非粘连性前置胎盘和 112 例年龄和 BMI 匹配的健康妊娠对照组。从实验室数据文件中获取 PIGF 中位数倍数（MoM）。采用多因素逻辑回归分析胎盘植入的预测因素。
前置胎盘伴胎盘植入组的 PIGF MoM 明显高于非粘连性前置胎盘组和对照组（p=0.0098<0.01，p=0.0002<0.01）。调整采血时的孕周、BMI 和年龄后，血清 PIGF 与胎盘植入呈显著正相关（OR：4.83；95%CI：1.91-12.24；p=0.0009<0.01）。此外，既往剖宫产史（OR：2.75；95%CI：1.23-6.17；p=0.014<0.05）和吸烟（OR：9.17；95%CI：1.69-49.62；p=0.010<0.05）也与胎盘植入显著相关。
妊娠早期血清 PIGF 升高与胎盘植入显著正相关，提示 PIGF 可能在识别胎盘植入高危妊娠方面具有一定作用。既往剖宫产史和吸烟可能是前置胎盘患者发生胎盘植入的危险因素。
