Schulman S L, Deforest A, Kaiser B A, Polinsky M S, Baluarte H J
Department of Pediatrics, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania.
Pediatr Nephrol. 1992 Mar;6(2):187-9. doi: 10.1007/BF00866312.
Ten children receiving maintenance dialysis were immunized with the standard dose of measles-mumps-rubella vaccine between 15 and 33 months of age. Immune responses to vaccination were determined using commercially available enzyme-linked immunosorbent assays for measles, mumps, and rubella viruses. Eight children responded to measles vaccine, 5 to mumps vaccine, 8 to rubella vaccine, and only 3 children to all three vaccines, compared with a seroconversion rate of over 90% to all three vaccines in healthy children (P less than 0.0001). We contend that the relatively poor immunocompetence of our dialysis patients explains their less than optimal vaccine response and suggest that children vaccinated while undergoing dialysis be tested to confirm serological evidence of immunity.
10名接受维持性透析的儿童在15至33个月大时接种了标准剂量的麻疹-腮腺炎-风疹疫苗。使用市售的针对麻疹、腮腺炎和风疹病毒的酶联免疫吸附测定法来确定对疫苗接种的免疫反应。与健康儿童中三种疫苗的血清转化率均超过90%相比，8名儿童对麻疹疫苗有反应，5名对腮腺炎疫苗有反应，8名对风疹疫苗有反应，只有3名儿童对所有三种疫苗均有反应（P小于0.0001）。我们认为，我们的透析患者相对较差的免疫能力解释了他们欠佳的疫苗反应，并建议对透析期间接种疫苗的儿童进行检测，以确认免疫的血清学证据。
