Mander A J, Weppner G J, Chick J D, Morton J J, Best J J
Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, U.K.
Alcohol Alcohol. 1988;23(2):97-102.
Five chronic alcoholic patients admitted for detoxification were studied. During the first 24-48 hr of abstinence raised levels of cerebral water (as measured by NMR), vasopressin, renin and supine aldosterone were recorded. Initial vasopressin concentration was correlated (r = 0.88, P less than 0.05) with alcohol consumption in the week prior to admission and was over three times higher in the patients measured after 24-48 hr as compared to less than 24 hr. After one week only supine aldosterone was still raised (P less than 0.05). The results suggest that cerebral oedema occurs during the early stages of abstinence. The role of these changes in the aetiology of withdrawal symptoms, delirium tremens and brain damage remains to be elucidated.
对5名因戒酒入院的慢性酒精中毒患者进行了研究。在戒酒的最初24至48小时内，记录到脑含水量（通过核磁共振测量）、血管加压素、肾素和仰卧位醛固酮水平升高。初始血管加压素浓度与入院前一周的酒精摄入量相关（r = 0.88，P < 0.05），与测量时间少于24小时的患者相比，在24至48小时后测量的患者中其浓度高出三倍以上。一周后，仅仰卧位醛固酮水平仍升高（P < 0.05）。结果表明，脑水肿发生在戒酒的早期阶段。这些变化在戒断症状、震颤谵妄和脑损伤病因学中的作用仍有待阐明。
