Department of Odontology, Federal University of Pará, Street Augusto Corrêa, Number 01, 66075-110, Belém, PA, Brazil.
Radiotherapy Service of Hospital Ophir Loyola, Avenue. Gov Magalhães Barata, Number 992, 66060-281, Belém, PA, Brazil.
J Ethnopharmacol. 2021 Jan 10;264:113365. doi: 10.1016/j.jep.2020.113365. Epub 2020 Sep 10.
ETHNO-PHARMACOLOGICAL RELEVANCE: The Carapa guianensis Aubl, popularly known as andiroba, is a large tree of the Meliaceae family, commonly found in the Amazon region. The oil extracted from its seeds is recognized in traditional medicine and has high anti-inflammatory and analgesic potential, which are the basic prerequisites for a therapeutic agent that can be used in the treatment of oral mucositis (OM). Moreover, the aforementioned oil has antimicrobial, antiallergic, and parasiticidal actions and is effective in the management of cutaneous and muscular dysfunctions.
To evaluate the therapeutic effects of andiroba gel (Carapa guianensis Aubl) on the symptomatology and evolution of OM in children with leukemia who underwent chemotherapy and to compare it to the effects of low power laser.
This randomized, double-blind clinical trial involved 60 patients of both genders with leukemia, with age ranging from six to twelve years. The patients were divided into two study groups: the andiroba group (n = 30) and the laser group (n = 30). The level of pain experienced by the patients was assessed using the Wong-Baker visual analog scale and the degree of severity of OM was assessed using a table, recommended by the World Health Organization, that depicts the degrees of severity of OM. The data obtained were analyzed using the Mann-Whitney test, with statistical significance indicated by a P value less than or equal to 0.05.
A statistically significant reduction in the degree of OM was observed on the fourth, fifth, and sixth days and in the pain scores on the second, third, and fourth days in the andiroba group after the manifestation of OM, compared to the laser group.
The use of andiroba oil effectively reduced the severity of OM and relieved pain, which resulted in a decrease in the severity of signs and symptoms in the patients in the andiroba group, compared to the laser group.
Carapa guianensis Aubl，俗称andiroba，是桃金娘科的一种大树，常见于亚马逊地区。从其种子中提取的油在传统医学中得到认可，具有高抗炎和镇痛潜力，这是治疗口腔粘膜炎（OM）的治疗剂的基本前提。此外，上述油具有抗菌、抗过敏和驱虫作用，对皮肤和肌肉功能障碍的管理有效。
评估 andiroba 凝胶（Carapa guianensis Aubl）对接受化疗的白血病儿童 OM 症状和发展的治疗效果，并将其与低功率激光的效果进行比较。
这是一项随机、双盲临床试验，涉及 60 名年龄在 6 至 12 岁之间的男女白血病患者。患者分为两组：andiroba 组（n=30）和激光组（n=30）。使用 Wong-Baker 视觉模拟量表评估患者的疼痛程度，使用世界卫生组织推荐的表格评估 OM 的严重程度，该表格描述了 OM 的严重程度。使用 Mann-Whitney 检验分析获得的数据，统计显著性由 P 值小于或等于 0.05 表示。
在 OM 表现后的第四天、第五天和第六天，以及在 OM 组中，疼痛评分在第二天、第三天和第四天均观察到 OM 严重程度的统计学显著降低，与激光组相比。
使用 andiroba 油可有效降低 OM 的严重程度并缓解疼痛，与激光组相比，andiroba 组患者的症状和体征严重程度降低。
