Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil; Post-Graduation Program in Microbial Biology, Institute of Biological Sciences, University of Brasilia, Campus Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil.
J Ethnopharmacol. 2024 Jun 12;327:118004. doi: 10.1016/j.jep.2024.118004. Epub 2024 Mar 1.
Andiroba seed oil (Carapa guianensis Aubl.) is widely used by traditional populations in tropical countries, especially in the Brazilian Amazon, because of its anti-inflammatory, antirheumatic, antiseptic, healing and antipyretic properties, among others, which makes it useful for the treatment, mainly, of skin afflictions and wounds.
To describe the modulation of the immune system by andiroba oil (Carapa guianensis Aubl.) in inflammation and wound healing.
A scoping review was performed, following the recommendations of the Joanna Briggs Institute (JBI) and PRISMA for Scoping Reviews (PRISMA-ScR). As inclusion criteria, in vitro, in vivo, ex vivo, and clinical studies were selected, in Portuguese, English, or Spanish, in thirteen databases of published studies, gray literature, and references of the included studies, which deal with immune modulation by andiroba oil in the context of the various therapeutic applications that make use of its anti-inflammatory and wound healing properties. The selection of information sources was carried out by two independent reviewers between November 2022 and January 2023. The process of data extraction and evidence analysis was conducted by four pairs of independent reviewers between January and February 2023.
22 sources of evidence were included in this scoping review, mostly scientific articles published between 2005 and 2021 with in vivo sampling. The evidence suggests that andiroba oil reduces inflammation and promotes the healing of wounds of multiple etiologies by reducing leukocyte infiltration, increasing phagocytic activity, enhancing interleukin and inflammatory cytokine activity, promoting fibroblast recovery, increasing growth factors, reducing apoptotic cells, promoting reepithelialization, as well as promoting angiogenesis, reducing edema, and stimulating the production of glucocorticoids that alleviate pain. Additionally, different formulations of the oil (such as nanoemulsions, films and gels) are more effective in modulating inflammation and wound healing compared to in natura oil.
Evidence in the literature suggests that andiroba oil (Carapa guianensis Aubl.) has positive effects on immune modulation in inflammation and wound healing, which makes it a biocompound with high therapeutic potential.
巴西可可树籽油（Carapa guianensis Aubl.）因其具有抗炎、抗风湿、防腐、愈合和退热等特性，被热带国家的传统人群广泛使用，尤其是在巴西亚马逊地区，这使其成为治疗皮肤疾病和伤口的有效药物。
描述巴西可可树籽油（Carapa guianensis Aubl.）在炎症和伤口愈合过程中对免疫系统的调节作用。
根据乔安娜·布里格斯研究所（Joanna Briggs Institute，JBI）和用于范围综述的 PRISMA 建议（PRISMA-ScR），进行了范围综述。纳入标准为：在体外、体内、离体和临床研究中，选择了以葡萄牙语、英语或西班牙语发表的研究，涉及在巴西可可树籽油的各种治疗应用中对免疫系统的调节作用，这些应用利用了其抗炎和伤口愈合特性。信息源的选择由两位独立评审员于 2022 年 11 月至 2023 年 1 月进行。数据提取和证据分析过程由四对独立评审员于 2023 年 1 月至 2 月进行。
本范围综述共纳入 22 个证据来源，其中大多数为 2005 年至 2021 年发表的科学文章，涉及体内采样。这些证据表明，巴西可可树籽油通过减少白细胞浸润、增加吞噬作用、增强白细胞介素和炎症细胞因子活性、促进成纤维细胞恢复、增加生长因子、减少凋亡细胞、促进再上皮化以及促进血管生成、减少水肿和刺激减轻疼痛的糖皮质激素的产生，来减轻炎症并促进多种病因引起的伤口愈合。此外，与天然油相比，油的不同制剂（如纳米乳液、薄膜和凝胶）在调节炎症和伤口愈合方面更有效。
文献中的证据表明，巴西可可树籽油（Carapa guianensis Aubl.）对炎症和伤口愈合过程中的免疫调节具有积极影响，这使其成为一种具有高治疗潜力的生物化合物。
