Department of Obstetrics and Gynecology, Division of Perinatology, Tepecik Training and Research Hospital, Izmir, Turkey.
J Perinat Med. 2020 Sep 14;49(2):170-177. doi: 10.1515/jpm-2020-0147. Print 2021 Feb 23.
This study aims to present the termination of pregnancy (TOP) rates and elucidate the decision-making process following a prenatal diagnosis of Trisomy 21 in Turkey.
This retrospective single-center study was conducted with 146 pregnant women between January 2016 and December 2019 in a tertiary hospital. Data on maternal characteristics, sonographic findings, indications for chromosome analysis, and educational, religious, and economic factors that can influence the parental decision process were collected.
The TOP rate of Down syndrome (DS) in our center was 78.8%. We concluded that maternal age, earlier diagnosis, indication for chromosome analysis, and previous pregnancies had no effect on the TOP decision. On the other hand, not having a minor or a major sonographic sign, employed mothers, middle- and high-income families, and families having a secondary or higher education tended to terminate the pregnancy affected by DS at statistically higher rates.
There are many studies worldwide investigating the TOP preferences for DS. However, there is limited data about TOP rates and influential factors affecting the decision-making process in Muslim countries. This study contributes by clarifying the factors in the decision-making process and elucidating perspectives about TOP in a Muslim country with a unique status: Turkey.
本研究旨在介绍土耳其唐氏综合征产前诊断后终止妊娠（TOP）的比率，并阐明决策过程。
这是一项回顾性单中心研究，纳入了 2016 年 1 月至 2019 年 12 月在一家三级医院就诊的 146 名孕妇。收集了母亲特征、超声发现、染色体分析指征以及可能影响父母决策过程的教育、宗教和经济因素的数据。
我们中心唐氏综合征（DS）的 TOP 率为 78.8%。我们得出结论，母亲年龄、早期诊断、染色体分析指征以及既往妊娠对 TOP 决策没有影响。另一方面，没有小或大的超声征象、职业母亲、中高收入家庭以及具有中等或高等教育程度的家庭，往往更倾向于终止受 DS 影响的妊娠，这一结果具有统计学意义。
全世界有许多研究调查了唐氏综合征的 TOP 偏好。然而，穆斯林国家关于 TOP 率和影响决策过程的因素的数据有限。本研究通过阐明决策过程中的因素，并阐明在具有独特地位的穆斯林国家（土耳其）终止妊娠的观点，为这一领域做出了贡献。
