German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Clinical Nutrition, 14558, Nuthetal, Germany.
Charité University Medicine Berlin, Department of Endocrinology, 10117, Berlin, Germany.
Mol Nutr Food Res. 2020 Nov;64(21):e2000419. doi: 10.1002/mnfr.202000419. Epub 2020 Oct 7.
Effective treatment for obesity associated non-alcoholic fatty liver disease (NAFLD) is limited. Dietary supplementation of n-3 polyunsaturated fatty acids, specifically alpha linolenic acid (ALA), can resolve intrahepatic lipid content (IHL). This study investigates the effect of daily supplementation of either refined rapeseed (RA), containing high amounts of ALA, or refined olive (OL) oil on IHL and glucose metabolism in NAFLD patients.
27 obese men consumed an isocaloric diet including either 50 g of RA or OL daily for 8 weeks. Hepatic proton magnetic resonance spectroscopy, hyperinsulinemic-euglycemic clamp studies and blood tests are performed before and at the end of the study. At 8 weeks a significant reduction in IHL is observed for RA (13.1 ± 1.6 before versus 11.1 ± 1.6% after intervention) versus OL (13.3 ± 2.5 before versus 15.7 ± 2.7% after intervention). For RA, a 21% reduction (P < 0.02) in serum free fatty acids (FFA) and a 1.68-fold increase (P = 0.03) of serum interleukin-6 (IL-6) is observed after 8 weeks.
RA has a beneficial effect on hepatic lipid metabolism as shown by reduced IHL and serum FFA. RA induced IL-6 production seems to be liver protective confirming previous results.
肥胖相关非酒精性脂肪性肝病（NAFLD）的有效治疗方法有限。膳食补充 n-3 多不饱和脂肪酸，特别是α亚麻酸（ALA），可以解决肝内脂质含量（IHL）问题。本研究旨在探讨每日补充精制油菜籽油（RA）或精制橄榄油（OL）对 NAFLD 患者 IHL 和葡萄糖代谢的影响。
27 名肥胖男性摄入等热量饮食，每日分别包含 50 克 RA 或 OL，持续 8 周。在研究前后进行肝质子磁共振波谱、高胰岛素-正常血糖钳夹研究和血液检查。8 周后，RA 组的 IHL 显著降低（13.1 ± 1.6 干预前与 11.1 ± 1.6%干预后），而 OL 组则无明显变化（13.3 ± 2.5 干预前与 15.7 ± 2.7%干预后）。RA 组血清游离脂肪酸（FFA）降低 21%（P < 0.02），血清白细胞介素-6（IL-6）增加 1.68 倍（P = 0.03）。
RA 对肝脂质代谢有有益影响，表现为 IHL 和血清 FFA 降低。RA 诱导的 IL-6 产生似乎具有肝脏保护作用，这与之前的结果一致。
